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Cancers 2019, 11(3), 287; https://doi.org/10.3390/cancers11030287

Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation

1
Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, E-08028 Barcelona, Spain
2
Departament de Patologia i Terapèutica Experimental, Hospital Universitari de Bellvitge-IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
3
Departament de Ciències Morfològiques, Parc Taulí Hospital Universitari, Universitat Autònoma de Barcelona, 08208 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Received: 26 January 2019 / Revised: 21 February 2019 / Accepted: 24 February 2019 / Published: 1 March 2019
(This article belongs to the Special Issue Ion Channels in Cancer)
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Abstract

Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control. Therefore, Kv remarkably participate in the cell function by balancing responses. The implication of Kv in physiological and pathophysiological cell growth is the subject of study, as Kv are proposed as therapeutic targets for tumor regression. Though it is widely accepted that Kv channels control proliferation by allowing cell cycle progression, their role is controversial. Kv expression is altered in many cancers, and their participation, as well as their use as tumor markers, is worthy of effort. There is an ever-growing list of Kv that remodel during tumorigenesis. This review focuses on the actual knowledge of Kv channel expression and their relationship with neoplastic proliferation. In this work, we provide an update of what is currently known about these proteins, thereby paving the way for a more precise understanding of the participation of Kv during cancer development. View Full-Text
Keywords: K+ channels; cancer; tumor progression; cell cycle; proliferation K+ channels; cancer; tumor progression; cell cycle; proliferation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Serrano-Novillo, C.; Capera, J.; Colomer-Molera, M.; Condom, E.; Ferreres, J.C.; Felipe, A. Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation. Cancers 2019, 11, 287.

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