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Cancers 2019, 11(2), 179;

Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029

Université Clermont Auvergne, INSERM1071, Microbes, Intestins, Inflammation et Susceptibilité de l’hôte, 63001 Clermont-Ferrand CEDEX 1, France
Université Clermont Auvergne, INSERM U1240, Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France
Université Paris-Sud, INSERM U935, Bâtiment Lavoisier, 14 Avenue Paul-Vaillant-Couturier, F-94800 Villejuif, France
Department of Pain and Palliative Medicine AP HP, Hôpital Necker, 75015 Paris, France
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 19 December 2018 / Revised: 28 January 2019 / Accepted: 30 January 2019 / Published: 3 February 2019
PDF [2369 KB, uploaded 4 February 2019]
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Tetraspanins are exposed at the surface of cellular membranes, which allows for the fixation of cognate antibodies. Developing specific antibodies in conjunction with genetic data would largely contribute to deciphering their biological behavior. In this short review, we summarize the main functions of Tspan8/Co-029 and its role in the biology of tumor cells. Based on data collected from recently reported studies, the possibilities of using antibodies to target Tspan8 in immunotherapy or radioimmunotherapy approaches are also discussed. View Full-Text
Keywords: tetraspanins; cancer; Tspan8; immunotherapy; radioimmunotherapy tetraspanins; cancer; Tspan8; immunotherapy; radioimmunotherapy

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Bonnet, M.; Maisonial-Besset, A.; Zhu, Y.; Witkowski, T.; Roche, G.; Boucheix, C.; Greco, C.; Degoul, F. Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029. Cancers 2019, 11, 179.

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