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Review

Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research

1
Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast BT9 7AE, Northern Ireland, UK
2
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1088, USA
3
In vivo Imaging, Discovery and Analytics, PerkinElmer Inc., Hopkinton, MA 01748, USA
4
Department of Radiation Oncology, Stanford University, Stanford, CA 94305-5152, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(2), 170; https://doi.org/10.3390/cancers11020170
Received: 14 December 2018 / Revised: 23 January 2019 / Accepted: 29 January 2019 / Published: 1 February 2019
(This article belongs to the Special Issue New Developments in Radiotherapy)
Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects of the clinical scenario in radiation oncology is critical to translational success. The use of small animal irradiators with disease relevant mouse models and advanced in vivo imaging approaches offers unique possibilities to interrogate the radiotherapy response of tumors and normal tissues with high potential to translate to improvements in clinical outcomes. The present review highlights the current technology and applications of small animal irradiators, and explores how these can be combined with molecular and functional imaging in advanced preclinical radiotherapy research. View Full-Text
Keywords: preclinical radiotherapy; functional imaging; small animal irradiators; radiobiology; radiation oncology preclinical radiotherapy; functional imaging; small animal irradiators; radiobiology; radiation oncology
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MDPI and ACS Style

Ghita, M.; Brown, K.H.; Kelada, O.J.; Graves, E.E.; Butterworth, K.T. Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research. Cancers 2019, 11, 170. https://doi.org/10.3390/cancers11020170

AMA Style

Ghita M, Brown KH, Kelada OJ, Graves EE, Butterworth KT. Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research. Cancers. 2019; 11(2):170. https://doi.org/10.3390/cancers11020170

Chicago/Turabian Style

Ghita, Mihaela, Kathryn H. Brown, Olivia J. Kelada, Edward E. Graves, and Karl T. Butterworth 2019. "Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research" Cancers 11, no. 2: 170. https://doi.org/10.3390/cancers11020170

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