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T-type Calcium Channels in Cancer

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA
Author to whom correspondence should be addressed.
Cancers 2019, 11(2), 134;
Received: 10 December 2018 / Revised: 10 January 2019 / Accepted: 17 January 2019 / Published: 23 January 2019
(This article belongs to the Special Issue Ion Channels in Cancer)
Although voltage-activated Ca2+ channels are a common feature in excitable cells, their expression in cancer tissue is less understood. T-type Ca2+ channels are particularly overexpressed in various cancers. Because of their activation profile at membrane potentials close to rest and the generation of a window current, T-type Ca2+ channels may regulate a variety of Ca2+-dependent cellular processes, including cell proliferation, survival, and differentiation. The expression of T-type Ca2+ channels is of special interest as a target for therapeutic interventions. View Full-Text
Keywords: T-type Ca2+ channel; cancer; proliferation; neuroendocrine differentiation T-type Ca2+ channel; cancer; proliferation; neuroendocrine differentiation
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Antal, L.; Martin-Caraballo, M. T-type Calcium Channels in Cancer. Cancers 2019, 11, 134.

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