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T-type Calcium Channels in Cancer

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA
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Author to whom correspondence should be addressed.
Cancers 2019, 11(2), 134; https://doi.org/10.3390/cancers11020134
Received: 10 December 2018 / Revised: 10 January 2019 / Accepted: 17 January 2019 / Published: 23 January 2019
(This article belongs to the Special Issue Ion Channels in Cancer)
Although voltage-activated Ca2+ channels are a common feature in excitable cells, their expression in cancer tissue is less understood. T-type Ca2+ channels are particularly overexpressed in various cancers. Because of their activation profile at membrane potentials close to rest and the generation of a window current, T-type Ca2+ channels may regulate a variety of Ca2+-dependent cellular processes, including cell proliferation, survival, and differentiation. The expression of T-type Ca2+ channels is of special interest as a target for therapeutic interventions. View Full-Text
Keywords: T-type Ca2+ channel; cancer; proliferation; neuroendocrine differentiation T-type Ca2+ channel; cancer; proliferation; neuroendocrine differentiation
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Antal, L.; Martin-Caraballo, M. T-type Calcium Channels in Cancer. Cancers 2019, 11, 134.

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