Although voltage-activated Ca2+
channels are a common feature in excitable cells, their expression in cancer tissue is less understood. T-type Ca2+
channels are particularly overexpressed in various cancers. Because of their activation profile at membrane potentials close to rest and the generation of a window current, T-type Ca2+
channels may regulate a variety of Ca2+
-dependent cellular processes, including cell proliferation, survival, and differentiation. The expression of T-type Ca2+
channels is of special interest as a target for therapeutic interventions.
This is an open access article distributed under the Creative Commons Attribution License
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited