A Role for the Biological Clock in Liver Cancer
Abstract
:1. Introduction
2. The Circadian Clock Circuitry and the Molecular Mechanisms of Hepatocellular Carcinogenesis
3. The Biological Clock and the Oncogenic Pathways Involved in Hepatocarcinogenesis
3.1. WNT/β-Catenin Signaling Pathway
3.2. Hedgehog Signaling Pathway
3.3. MAP Kinase Signaling Pathways
3.4. PI3K/AKT/mTOR Signaling Pathway
3.5. Epigenetics
4. The Biological Clock and Systemic Therapy in Hepatocellular Carcinoma
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Mazzoccoli, G.; Miele, L.; Marrone, G.; Mazza, T.; Vinciguerra, M.; Grieco, A. A Role for the Biological Clock in Liver Cancer. Cancers 2019, 11, 1778. https://doi.org/10.3390/cancers11111778
Mazzoccoli G, Miele L, Marrone G, Mazza T, Vinciguerra M, Grieco A. A Role for the Biological Clock in Liver Cancer. Cancers. 2019; 11(11):1778. https://doi.org/10.3390/cancers11111778
Chicago/Turabian StyleMazzoccoli, Gianluigi, Luca Miele, Giuseppe Marrone, Tommaso Mazza, Manlio Vinciguerra, and Antonio Grieco. 2019. "A Role for the Biological Clock in Liver Cancer" Cancers 11, no. 11: 1778. https://doi.org/10.3390/cancers11111778
APA StyleMazzoccoli, G., Miele, L., Marrone, G., Mazza, T., Vinciguerra, M., & Grieco, A. (2019). A Role for the Biological Clock in Liver Cancer. Cancers, 11(11), 1778. https://doi.org/10.3390/cancers11111778