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Open AccessArticle

Unclassifiable Isolated Monoclonal Lymphocytosis: Comprehensive Description of a Retrospective Cohort

1
Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Laboratoire d’hématologie, 69495 Pierre Bénite, France
2
INSERM 1052, CNRS 5286, Université Claude Bernard, Faculté de Médecine Lyon-Sud Charles Mérieux, Université de Lyon, 69495 Pierre Bénite, France
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Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Laboratoire d’anatomopathologie, 69495 Pierre Bénite, France
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Assistance Publique—Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département d’hématologie biologique, Sorbonne Université, 75013 Paris, France
5
Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d’hématologie clinique, 69495 Pierre Bénite, France
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(10), 1495; https://doi.org/10.3390/cancers11101495
Received: 23 June 2019 / Revised: 17 September 2019 / Accepted: 30 September 2019 / Published: 4 October 2019
According to the World Health Organization (WHO) classification, the nosology of B-cell neoplasms integrates clinical, morphological, phenotypic, and genetic data. In this retrospective analysis, we identified 18 patients with isolated neoplastic lymphocytosis that could not be accurately classified within the WHO classification. Most of them were asymptomatic at the time of diagnosis and the evolution was relatively indolent, as only five patients required treatment after a median follow-up of 48 months. The neoplastic B-cells expressed CD5 in most cases, but the Royal Marsden Hospital score was strictly below 3. Trisomy 12 was the most frequent cytogenetic abnormality. High-throughput sequencing highlighted mutations found in both chronic lymphocytic leukemia (CLL) and marginal zone lymphoma (MZL). Similarly, the immunoglobulin heavy chain variable region repertoire was distinct from those reported in CLL or MZL. However, as treatment choice is dependent on the correct classification of the lymphoproliferative disorder, a histological diagnosis should be performed in case patients need to be treated. View Full-Text
Keywords: WHO classification; lymphocytosis; B-cell neoplasms; chronic lymphocytic leukemia; marginal zone lymphoma WHO classification; lymphocytosis; B-cell neoplasms; chronic lymphocytic leukemia; marginal zone lymphoma
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Degaud, M.; Baseggio, L.; Grange, B.; Manzoni, D.; Huet, S.; Callet-Bauchu, E.; Traverse-Glehen, A.; Davi, F.; Ghesquières, H.; Salles, G.; Sujobert, P. Unclassifiable Isolated Monoclonal Lymphocytosis: Comprehensive Description of a Retrospective Cohort. Cancers 2019, 11, 1495.

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