Next Article in Journal
Lower Extremity Lymphedema in Gynecologic Cancer Patients: Propensity Score Matching Analysis of External Beam Radiation versus Brachytherapy
Previous Article in Journal
Effects of Aspirin or Clopidogrel on Colorectal Cancer Chemoprevention in Patients with Type 2 Diabetes Mellitus
Previous Article in Special Issue
Targeting of CD133+ Cancer Stem Cells by Mesenchymal Stem Cell Expressing TRAIL Reveals a Prospective Role of Apoptotic Gene Regulation in Non-Small Cell Lung Cancer
Open AccessReview

The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses

1
Izmir Biomedicine and Genome Center (IBG), 35340 Balcova/Izmir, Turkey
2
Department of Medical Biology, Faculty of Medicine, Dokuz Eylul University, 35340 Balcova/Izmir, Turkey
3
Department of Genome Sciences and Molecular Biotechnology, Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, 35340 Balcova/Izmir, Turkey
4
Department of Biomedicine and Health Technologies, Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, 35340 Balcova/Izmir, Turkey
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(10), 1469; https://doi.org/10.3390/cancers11101469
Received: 12 August 2019 / Revised: 9 September 2019 / Accepted: 20 September 2019 / Published: 30 September 2019
(This article belongs to the Special Issue TRAIL Signaling in Cancer Cells)
Expression of TRAIL (tumor necrosis factor–related apoptosis–inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence immune responses. Here, we review what is known about the role of TRAIL/DRs in immune cells and immune responses in general and in the tumor microenvironment in particular. View Full-Text
Keywords: apoptosis; immune regulation; tumor; myeloid cells; lymphoid cells apoptosis; immune regulation; tumor; myeloid cells; lymphoid cells
Show Figures

Figure 1

MDPI and ACS Style

Sag, D.; Ayyildiz, Z.O.; Gunalp, S.; Wingender, G. The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses. Cancers 2019, 11, 1469.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop