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Open AccessEditor’s ChoiceArticle

Elevated Polyamines in Saliva of Pancreatic Cancer

1
Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan
2
Research and Development Center for Minimally Invasive Therapies Health Promotion and Preemptive Medicine, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan
3
Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan
4
Third Department of Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan
5
Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo 190-0998, Japan
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(2), 43; https://doi.org/10.3390/cancers10020043
Received: 10 January 2018 / Revised: 26 January 2018 / Accepted: 2 February 2018 / Published: 5 February 2018
(This article belongs to the Special Issue Latest Development in Pancreatic Cancer)
Detection of pancreatic cancer (PC) at a resectable stage is still difficult because of the lack of accurate detection tests. The development of accurate biomarkers in low or non-invasive biofluids is essential to enable frequent tests, which would help increase the opportunity of PC detection in early stages. Polyamines have been reported as possible biomarkers in urine and saliva samples in various cancers. Here, we analyzed salivary metabolites, including polyamines, using capillary electrophoresis-mass spectrometry. Salivary samples were collected from patients with PC (n = 39), those with chronic pancreatitis (CP, n = 14), and controls (C, n = 26). Polyamines, such as spermine, N1-acetylspermidine, and N1-acetylspermine, showed a significant difference between patients with PC and those with C, and the combination of four metabolites including N1-acetylspermidine showed high accuracy in discriminating PC from the other two groups. These data show the potential of saliva as a source for tests screening for PC. View Full-Text
Keywords: pancreatic cancer; saliva; metabolomics; polyamines pancreatic cancer; saliva; metabolomics; polyamines
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MDPI and ACS Style

Asai, Y.; Itoi, T.; Sugimoto, M.; Sofuni, A.; Tsuchiya, T.; Tanaka, R.; Tonozuka, R.; Honjo, M.; Mukai, S.; Fujita, M.; Yamamoto, K.; Matsunami, Y.; Kurosawa, T.; Nagakawa, Y.; Kaneko, M.; Ota, S.; Kawachi, S.; Shimazu, M.; Soga, T.; Tomita, M.; Sunamura, M. Elevated Polyamines in Saliva of Pancreatic Cancer. Cancers 2018, 10, 43. https://doi.org/10.3390/cancers10020043

AMA Style

Asai Y, Itoi T, Sugimoto M, Sofuni A, Tsuchiya T, Tanaka R, Tonozuka R, Honjo M, Mukai S, Fujita M, Yamamoto K, Matsunami Y, Kurosawa T, Nagakawa Y, Kaneko M, Ota S, Kawachi S, Shimazu M, Soga T, Tomita M, Sunamura M. Elevated Polyamines in Saliva of Pancreatic Cancer. Cancers. 2018; 10(2):43. https://doi.org/10.3390/cancers10020043

Chicago/Turabian Style

Asai, Yasutsugu; Itoi, Takao; Sugimoto, Masahiro; Sofuni, Atsushi; Tsuchiya, Takayoshi; Tanaka, Reina; Tonozuka, Ryosuke; Honjo, Mitsuyoshi; Mukai, Shuntaro; Fujita, Mitsuru; Yamamoto, Kenjiro; Matsunami, Yukitoshi; Kurosawa, Takashi; Nagakawa, Yuichi; Kaneko, Miku; Ota, Sana; Kawachi, Shigeyuki; Shimazu, Motohide; Soga, Tomoyoshi; Tomita, Masaru; Sunamura, Makoto. 2018. "Elevated Polyamines in Saliva of Pancreatic Cancer" Cancers 10, no. 2: 43. https://doi.org/10.3390/cancers10020043

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