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Open AccessFeature PaperReview

Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals

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Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA
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Department of Immunology, Duke University, Durham, NC 27710, USA
*
Author to whom correspondence should be addressed.
Micromachines 2018, 9(9), 428; https://doi.org/10.3390/mi9090428
Received: 31 July 2018 / Revised: 17 August 2018 / Accepted: 23 August 2018 / Published: 25 August 2018
(This article belongs to the Special Issue Neural Microelectrodes: Design and Applications)
Advanced electrode designs have made single-unit neural recordings commonplace in modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system. Single-unit recordings of the enteric (gut) nervous system have been conducted in anesthetized animal models and excised tissue, but there is a large physiological gap between awake and anesthetized animals, particularly for the enteric nervous system. Here, we describe the opportunity for advancing enteric neuroscience offered by single-unit recording capabilities in awake animals. We highlight the primary challenges to microelectrodes in the gastrointestinal system including structural, physiological, and signal quality challenges, and we provide design criteria recommendations for enteric microelectrodes. View Full-Text
Keywords: microelectrodes; in vivo electrophysiology; neural interfaces; enteric nervous system; conscious recording; electrode implantation microelectrodes; in vivo electrophysiology; neural interfaces; enteric nervous system; conscious recording; electrode implantation
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MDPI and ACS Style

Barth, B.B.; Huang, H.-I.; Hammer, G.E.; Shen, X. Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals. Micromachines 2018, 9, 428.

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