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Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications

Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USA
Department of Chemistry and Physics, School of Arts and Sciences, LeTourneau University, Longview, TX 75607, USA
Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
Author to whom correspondence should be addressed.
Micromachines 2018, 9(5), 243;
Received: 15 April 2018 / Revised: 11 May 2018 / Accepted: 16 May 2018 / Published: 17 May 2018
(This article belongs to the Special Issue Biomedical Applications of Nanotechnology and Nanomaterials)
PDF [1892 KB, uploaded 17 May 2018]


Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering. Owing to these unique properties, this review focuses on the grafting of macromolecules on the surfaces of various biomaterials (e.g., films, fibers, hydrogels, and etc.) to create nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications, such as thrombosis prevention and wound healing. The macromolecule-modified surfaces can be treated as a functional device that either passively inhibits adverse effects from injectable and implantable devices or actively delivers biological agents that are locally based on proper stimulation. In this review, several methods are discussed to enable the surface of biomaterials to be used for further grafting of macromolecules. In addition, we review surface-modified films (coatings) and fibers with respect to several biomedical applications. Our review provides a scientific update on the current achievements and future trends of nanostructure-enabled and macromolecule-grafted surfaces in biomedical applications. View Full-Text
Keywords: macromolecules; grafting; surfaces; thrombosis; wound healing macromolecules; grafting; surfaces; thrombosis; wound healing

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Small, M.; Faglie, A.; Craig, A.J.; Pieper, M.; Fernand Narcisse, V.E.; Neuenschwander, P.F.; Chou, S.-F. Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications. Micromachines 2018, 9, 243.

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