Next Article in Journal
Energy Harvesting Combat Boot for Satellite Positioning
Previous Article in Journal
Micromachined Planar Supercapacitor with Interdigital Buckypaper Electrodes
Previous Article in Special Issue
Matrix Effect Study and Immunoassay Detection Using Electrolyte-Gated Graphene Biosensor
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessFeature PaperReview

Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications

1
Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USA
2
Department of Chemistry and Physics, School of Arts and Sciences, LeTourneau University, Longview, TX 75607, USA
3
Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
*
Author to whom correspondence should be addressed.
Micromachines 2018, 9(5), 243; https://doi.org/10.3390/mi9050243
Received: 15 April 2018 / Revised: 11 May 2018 / Accepted: 16 May 2018 / Published: 17 May 2018
(This article belongs to the Special Issue Biomedical Applications of Nanotechnology and Nanomaterials)
  |  
PDF [1892 KB, uploaded 17 May 2018]
  |  

Abstract

Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering. Owing to these unique properties, this review focuses on the grafting of macromolecules on the surfaces of various biomaterials (e.g., films, fibers, hydrogels, and etc.) to create nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications, such as thrombosis prevention and wound healing. The macromolecule-modified surfaces can be treated as a functional device that either passively inhibits adverse effects from injectable and implantable devices or actively delivers biological agents that are locally based on proper stimulation. In this review, several methods are discussed to enable the surface of biomaterials to be used for further grafting of macromolecules. In addition, we review surface-modified films (coatings) and fibers with respect to several biomedical applications. Our review provides a scientific update on the current achievements and future trends of nanostructure-enabled and macromolecule-grafted surfaces in biomedical applications. View Full-Text
Keywords: macromolecules; grafting; surfaces; thrombosis; wound healing macromolecules; grafting; surfaces; thrombosis; wound healing
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Small, M.; Faglie, A.; Craig, A.J.; Pieper, M.; Fernand Narcisse, V.E.; Neuenschwander, P.F.; Chou, S.-F. Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications. Micromachines 2018, 9, 243.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top