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Micromachines 2018, 9(10), 500; https://doi.org/10.3390/mi9100500

Chronic Intracortical Recording and Electrochemical Stability of Thiol-ene/Acrylate Shape Memory Polymer Electrode Arrays

1
Department of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA
2
Qualia, Inc., Dallas, TX 75252, USA
3
Department of Materials Science and Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA
*
Author to whom correspondence should be addressed.
Received: 18 August 2018 / Revised: 24 September 2018 / Accepted: 27 September 2018 / Published: 29 September 2018
(This article belongs to the Special Issue Neural Microelectrodes: Design and Applications)
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Abstract

Current intracortical probe technology is limited in clinical implementation due to the short functional lifetime of implanted devices. Devices often fail several months to years post-implantation, likely due to the chronic immune response characterized by glial scarring and neuronal dieback. It has been demonstrated that this neuroinflammatory response is influenced by the mechanical mismatch between stiff devices and the soft brain tissue, spurring interest in the use of softer polymer materials for probe encapsulation. Here, we demonstrate stable recordings and electrochemical properties obtained from fully encapsulated shape memory polymer (SMP) intracortical electrodes implanted in the rat motor cortex for 13 weeks. SMPs are a class of material that exhibit modulus changes when exposed to specific conditions. The formulation used in these devices softens by an order of magnitude after implantation compared to its dry, room-temperature modulus of ~2 GPa. View Full-Text
Keywords: intracortical implant; microelectrodes; softening; immunohistochemistry; immune response; neural interface; shape memory polymer intracortical implant; microelectrodes; softening; immunohistochemistry; immune response; neural interface; shape memory polymer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Stiller, A.M.; Usoro, J.; Frewin, C.L.; Danda, V.R.; Ecker, M.; Joshi-Imre, A.; Musselman, K.C.; Voit, W.; Modi, R.; Pancrazio, J.J.; Black, B.J. Chronic Intracortical Recording and Electrochemical Stability of Thiol-ene/Acrylate Shape Memory Polymer Electrode Arrays. Micromachines 2018, 9, 500.

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