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Micromachines 2017, 8(4), 124;

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

Future Industries Institute, University of South Australia, Mawson Lakes Blvd., Mawson Lakes, 5098 SA, Australia
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 VIC, Australia
Current address: National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia.
Author to whom correspondence should be addressed.
Academic Editors: Weihua Li, Hengdong Xi and Say Hwa Tan
Received: 28 February 2017 / Revised: 6 April 2017 / Accepted: 7 April 2017 / Published: 12 April 2017
(This article belongs to the Special Issue Insights and Advancements in Microfluidics)
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Many unique chemical compounds and nanomaterials are being developed, and each one requires a considerable range of in vitro and/or in vivo toxicity screening in order to evaluate their safety. The current methodology of in vitro toxicological screening on cells is based on well-plate assays that require time-consuming manual handling or expensive automation to gather enough meaningful toxicology data. Cost reduction; access to faster, more comprehensive toxicity data; and a robust platform capable of quantitative testing, will be essential in evaluating the safety of new chemicals and nanomaterials, and, at the same time, in securing the confidence of regulators and end-users. Microfluidic chips offer an alternative platform for toxicity screening that has the potential to transform both the rates and efficiency of nanomaterial testing, as reviewed here. The inherent advantages of microfluidic technologies offer high-throughput screening with small volumes of analytes, parallel analyses, and low-cost fabrication. View Full-Text
Keywords: microfluidics; cytotoxicity; nanotoxicity; nanoparticles; screening microfluidics; cytotoxicity; nanotoxicity; nanoparticles; screening

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McCormick, S.C.; Kriel, F.H.; Ivask, A.; Tong, Z.; Lombi, E.; Voelcker, N.H.; Priest, C. The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments. Micromachines 2017, 8, 124.

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