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Micromachines 2016, 7(12), 233;

Microfabricated Physiological Models for In Vitro Drug Screening Applications

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan 20133, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Dario Carugo and Xunli Zhang
Received: 15 November 2016 / Revised: 9 December 2016 / Accepted: 12 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Microfluidic Technologies for Drug Delivery)
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Microfluidics and microfabrication have recently been established as promising tools for developing a new generation of in vitro cell culture microdevices. The reduced amounts of reagents employed within cell culture microdevices make them particularly appealing to drug screening processes. In addition, latest advancements in recreating physiologically relevant cell culture conditions within microfabricated devices encourage the idea of using such advanced biological models in improving the screening of drug candidates prior to in vivo testing. In this review, we discuss microfluidics-based models employed for chemical/drug screening and the strategies to mimic various physiological conditions: fine control of 3D extra-cellular matrix environment, physical and chemical cues provided to cells and organization of co-cultures. We also envision future directions for achieving multi-organ microfluidic devices. View Full-Text
Keywords: microfluidics; drug screening; physiological models; organ-on-chips microfluidics; drug screening; physiological models; organ-on-chips

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ugolini, G.S.; Cruz-Moreira, D.; Visone, R.; Redaelli, A.; Rasponi, M. Microfabricated Physiological Models for In Vitro Drug Screening Applications. Micromachines 2016, 7, 233.

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