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Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices

1
Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA
2
Department of Mechanical Engineering, George Mason University, Fairfax, VA 22030, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Xiangchun Xuan and Hui Zhao
Micromachines 2021, 12(10), 1216; https://doi.org/10.3390/mi12101216
Received: 11 September 2021 / Revised: 1 October 2021 / Accepted: 3 October 2021 / Published: 6 October 2021
(This article belongs to the Special Issue X-fluidics at the Micro/Nanoscale)
For effective treatment of diseases such as cancer or fibrosis, it is essential to deliver therapeutic agents such as drugs to the diseased tissue, but these diseased sites are surrounded by a dense network of fibers, cells, and proteins known as the extracellular matrix (ECM). The ECM forms a barrier between the diseased cells and blood circulation, the main route of administration of most drug delivery nanoparticles. Hence, a stiff ECM impedes drug delivery by limiting the transport of drugs to the diseased tissue. The use of self-propelled particles (SPPs) that can move in a directional manner with the application of physical or chemical forces can help in increasing the drug delivery efficiency. Here, we provide a comprehensive look at the current ECM models in use to mimic the in vivo diseased states, the different types of SPPs that have been experimentally tested in these models, and suggest directions for future research toward clinical translation of SPPs in diverse biomedical settings. View Full-Text
Keywords: extracellular matrix; drug delivery; self-propelled particles; ECM; active colloids extracellular matrix; drug delivery; self-propelled particles; ECM; active colloids
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MDPI and ACS Style

Singh, S.; Moran, J.L. Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices. Micromachines 2021, 12, 1216. https://doi.org/10.3390/mi12101216

AMA Style

Singh S, Moran JL. Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices. Micromachines. 2021; 12(10):1216. https://doi.org/10.3390/mi12101216

Chicago/Turabian Style

Singh, Shrishti, and Jeffrey L. Moran. 2021. "Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices" Micromachines 12, no. 10: 1216. https://doi.org/10.3390/mi12101216

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