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Article

Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging

1
Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, Russia
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Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, Russia
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Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia
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Institute of Biochemistry and Physiology of Plants and Microorganisms, 410049 Saratov, Russia
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Department of Materials Science, Fudan University, Shanghai 200433, China
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Discipline of Physics, Indian Institute of Technology Gandhinagar Gandhinagar, Gujarat 382355, India
*
Author to whom correspondence should be addressed.
Academic Editor: Beatriz Jurado Sánchez
Micromachines 2021, 12(10), 1161; https://doi.org/10.3390/mi12101161
Received: 30 August 2021 / Revised: 23 September 2021 / Accepted: 25 September 2021 / Published: 27 September 2021
(This article belongs to the Special Issue Dream Nanomachines: Recent Advances in Nano/Micromotors)
Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications. View Full-Text
Keywords: microbubbles; bovine serum albumin; gold nanocages; zinc phthalocyanine; ultrasound imaging; fluorescence tomography; optoacoustic imaging; multimodal imaging microbubbles; bovine serum albumin; gold nanocages; zinc phthalocyanine; ultrasound imaging; fluorescence tomography; optoacoustic imaging; multimodal imaging
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MDPI and ACS Style

Maksimova, E.A.; Barmin, R.A.; Rudakovskaya, P.G.; Sindeeva, O.A.; Prikhozhdenko, E.S.; Yashchenok, A.M.; Khlebtsov, B.N.; Solovev, A.A.; Huang, G.; Mei, Y.; Kanti Dey, K.; Gorin, D.A. Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging. Micromachines 2021, 12, 1161. https://doi.org/10.3390/mi12101161

AMA Style

Maksimova EA, Barmin RA, Rudakovskaya PG, Sindeeva OA, Prikhozhdenko ES, Yashchenok AM, Khlebtsov BN, Solovev AA, Huang G, Mei Y, Kanti Dey K, Gorin DA. Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging. Micromachines. 2021; 12(10):1161. https://doi.org/10.3390/mi12101161

Chicago/Turabian Style

Maksimova, Elizaveta A., Roman A. Barmin, Polina G. Rudakovskaya, Olga A. Sindeeva, Ekaterina S. Prikhozhdenko, Alexey M. Yashchenok, Boris N. Khlebtsov, Alexander A. Solovev, Gaoshan Huang, Yongfeng Mei, Krishna Kanti Dey, and Dmitry A. Gorin 2021. "Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging" Micromachines 12, no. 10: 1161. https://doi.org/10.3390/mi12101161

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