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Review

Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering

School of Science and Technology, Department of Chemistry and Forensics, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
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Micromachines 2020, 11(9), 797; https://doi.org/10.3390/mi11090797
Received: 13 July 2020 / Revised: 20 August 2020 / Accepted: 21 August 2020 / Published: 22 August 2020
(This article belongs to the Special Issue Hybrid and Polymer Assemblies)
Tissue engineering (TE) is a highly multidisciplinary field that focuses on novel regenerative treatments and seeks to tackle problems relating to tissue growth both in vitro and in vivo. These issues currently involve the replacement and regeneration of defective tissues, as well as drug testing and other related bioapplications. The key approach in TE is to employ artificial structures (scaffolds) to support tissue development; these constructs should be capable of hosting, protecting and releasing bioactives that guide cellular behaviour. A straightforward approach to integrating bioactives into the scaffolds is discussed utilising polyelectrolyte multilayer capsules (PEMCs). Herein, this review illustrates the recent progress in the use of CaCO3 vaterite-templated PEMCs for the fabrication of functional scaffolds for TE applications, including bone TE as one of the main targets of PEMCs. Approaches for PEMC integration into scaffolds is addressed, taking into account the formulation, advantages, and disadvantages of such PEMCs, together with future perspectives of such architectures. View Full-Text
Keywords: CaCO3; growth factor; layer-by-layer; encapsulation CaCO3; growth factor; layer-by-layer; encapsulation
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MDPI and ACS Style

Kastania, G.; Campbell, J.; Mitford, J.; Volodkin, D. Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering. Micromachines 2020, 11, 797. https://doi.org/10.3390/mi11090797

AMA Style

Kastania G, Campbell J, Mitford J, Volodkin D. Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering. Micromachines. 2020; 11(9):797. https://doi.org/10.3390/mi11090797

Chicago/Turabian Style

Kastania, Georgia, Jack Campbell, Jacob Mitford, and Dmitry Volodkin. 2020. "Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering" Micromachines 11, no. 9: 797. https://doi.org/10.3390/mi11090797

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