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AC Electroosmosis Effect on Microfluidic Heterogeneous Immunoassay Efficiency

by Marwa Selmi 1,2,* and Hafedh Belmabrouk 2,3
1
Department of Radiological Sciences and Medical Imaging, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia
2
Laboratory of Electronics and Microelectronics, Faculty of Science of Monastir, University of Monastir, Environment Boulevard, Monastir 5019, Tunisia
3
Department of Physics, College of Sciences at Zulfi, Majmaah University, Majmaah 11952, Saudi Arabia
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(4), 342; https://doi.org/10.3390/mi11040342 (registering DOI)
Received: 19 February 2020 / Revised: 13 March 2020 / Accepted: 23 March 2020 / Published: 25 March 2020
A heterogeneous immunoassay is an efficient biomedical test. It aims to detect the presence of an analyte or to measure its concentration. It has many applications, such as manipulating particles and separating cancer cells from blood. The enhanced performance of immunosensors comes down to capturing more antigens with greater efficiency by antibodies in a short time. In this work, we report an efficient investigation of the effects of alternating current (AC) electrokinetic forces such as AC electroosmosis (ACEO), which arise when the fluid absorbs energy from an applied electric field, on the kinetics of the antigen–antibody binding in a flow system. The force can produce swirling structures in the fluid and, thus, improve the transport of the analyte toward the reaction surface of the immunosensor device. A numerical simulation is adequate for this purpose and may provide valuable information. The convection–diffusion phenomenon is coupled with the first-order Langmuir model. The governing equations are solved using the finite element method (FEM). The impact of AC electroosmosis on the binding reaction kinetics, the fluid flow stream modification, the analyte concentration diffusion, and the detection time of the biosensor under AC electroosmosis are analyzed. View Full-Text
Keywords: numerical simulation; immunosensor; alternating current electroosmosis (ACEO); detection time; performance biosensor numerical simulation; immunosensor; alternating current electroosmosis (ACEO); detection time; performance biosensor
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Selmi, M.; Belmabrouk, H. AC Electroosmosis Effect on Microfluidic Heterogeneous Immunoassay Efficiency. Micromachines 2020, 11, 342.

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