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Open AccessArticle

High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers

by Bing Sun 1,2 and Yiping Wang 1,2,*
1
Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
2
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, China
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(3), 270; https://doi.org/10.3390/mi11030270
Received: 22 January 2020 / Revised: 19 February 2020 / Accepted: 26 February 2020 / Published: 5 March 2020
The conventional methods for monitoring IgG levels suffer from some apparent problems such as long assay time, multistep processing, and high overall cost. An effective and suitable optical platform for label-free biosensing was investigated by the implementation of antibody/antigen immunoassays. The ultrasensitive detection of IgG levels could be achieved by exploiting the dispersion turning point (DTP) existing in the tapered two-mode fibers (TTMFs) because the sensitivity will reach ±∞ on either side of the DTP. Tracking the resonant wavelength shift, it was found that the fabricated TTMF device exhibited limits of detection (LOD) down to concentrations of 10 fg/mL of IgG in PBS solution. Such immunosensors based on DTP have great significance on trace detection of IgG due to simple detection scheme, quick response time, and miniaturization. View Full-Text
Keywords: biosensor; optical fiber sensor; two-mode fiber; sensitivity biosensor; optical fiber sensor; two-mode fiber; sensitivity
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Sun, B.; Wang, Y. High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers. Micromachines 2020, 11, 270.

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