Microfluidic Technology for Clinical Applications of Exosomes
Florina S. Iliescu 
1
School of Applied Science, Republic Polytechnic Singapore, Singapore 738964, Singapore
2
Laboratory of Microsensor Structures and Electronics, Faculty of Electrical Engineering, University of Ljubljana, SI-1000 Ljubljana, Slovenia
3
Ministry of Education Key Laboratory of Micro/Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, China
4
Central European Institute of Technology, Brno University of Technology, Brno 613 00, Czech Republic
5
Department of Microelectronics, Faculty of Electrical Engineering, Brno University of Technology, Technická 3058/10, 61600 Brno, Czech Republic
6
Biomedical Institute for Global Health Research and Technology (BIGHEART), National University of Singapore, Singapore 117599, Singapore
7
Academy of Romanian Scientists, Bucharest 050094, Romania
*
Authors to whom correspondence should be addressed.
Micromachines 2019, 10(6), 392; https://doi.org/10.3390/mi10060392
Received: 23 May 2019 / Revised: 6 June 2019 / Accepted: 7 June 2019 / Published: 12 June 2019
(This article belongs to the Special Issue Nanoparticles on Microfluidic Platforms)
Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases. This review introduces general aspects of exosomes, presents the challenges in exosome research, discusses the potential of exosomes as biomarkers, and describes the contribution of microfluidic technology to enable their isolation and analysis for diagnostic and disease monitoring. Additionally, clinical applications of exosomes for diagnostic purposes are also summarized.
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Keywords:
microfluidics; exosomes; clinical applications; extracellular vesicles; cancer; inflammation
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MDPI and ACS Style
Iliescu, F.S.; Vrtačnik, D.; Neuzil, P.; Iliescu, C. Microfluidic Technology for Clinical Applications of Exosomes. Micromachines 2019, 10, 392.
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