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Open AccessArticle

Facile Method for Fabricating Microfluidic Chip Integrated with Microwell Arrays for Cell Trapping

1
School of Mechanical Engineering and Automation, Northeastern University, Shenyang 110004, China
2
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
3
University of the Chinese Academy of Sciences, Beijing 100049, China
4
School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
*
Author to whom correspondence should be addressed.
Micromachines 2019, 10(11), 719; https://doi.org/10.3390/mi10110719
Received: 11 September 2019 / Revised: 23 October 2019 / Accepted: 24 October 2019 / Published: 25 October 2019
With the development of biomedical technology, personalized diagnosis and treatment at the single-cell level are becoming more important in the medical field. As one of the most powerful tools, microfluidic chips have shown significant potential for various applications related to cell separation, cell proliferation, and cell behavior analysis. However, fabricating microfluidic devices requires complicated procedures and high-cost equipment. In this study, an optofluidic maskless lithography method was proposed for rapid fabrication of microfluidic devices integrated with microwells. Through the use of this approach, microwells can be on-line designed and the exposure patterns can be modulated. Single or multi polystyrene microspheres were successfully trapped by using the designed microwells. The capture of MCF-7 cells and cell arrays indicated that the microfluidic devices fabricated in the present study can be applied for cell research. View Full-Text
Keywords: microstructure fabrication; microwell arrays; cell capture; microfluidic chip microstructure fabrication; microwell arrays; cell capture; microfluidic chip
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MDPI and ACS Style

Wu, H.; Ge, Z.; Yang, W.; Wang, X.; Wang, X.; Yu, H. Facile Method for Fabricating Microfluidic Chip Integrated with Microwell Arrays for Cell Trapping. Micromachines 2019, 10, 719.

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