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Open AccessArticle

Diabetogenic Effects of Ochratoxin A in Female Rats

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Istiklal Yerleskesi, Burdur 15030, Turkey
Department of Endocrinology and Metabolism, Faculty of Medicine, Pamukale University, Denizli 20070, Turkey
Division of Biology, Faculty of Science, Akdeniz University, Antalya 07058, Turkey
Department of Pathology, Istiklal Yerleskesi, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur 15030, Turkey
Author to whom correspondence should be addressed.
Toxins 2017, 9(4), 144;
Received: 24 February 2017 / Revised: 3 April 2017 / Accepted: 14 April 2017 / Published: 19 April 2017
(This article belongs to the Special Issue Impact of Human Metabolism on the Toxicological Effects of Mycotoxins)
In this study, the diabetogenic effects of long term Ochratoxin A (OTA) administration in rats were investigated, and its role in the etiology of diabetes mellitus (DM) was examined utilizing 42 female Wistar rats for these purposes. The rats were divided into three different study and control groups according to the duration of the OTA administration. The rats received 45 μg OTA daily in their feed for 6, 9 and 24 weeks, respectively. Three control groups were also used for the same time periods. Blood and pancreatic tissue samples were collected during the necropsy at the end of the 6, 9 and 24 weeks. The plasma values of insulin, glucagon and glucose were determined for the study and control groups. Pancreatic lesions were evaluated via histopathological examination and insulin and glucagon expression in these lesions was subsequently determined using immunohistochemical methods. Statistically significant decreases in insulin levels were observed, in contrast to increases in blood glucagon and glucose levels. Histopathological examinations revealed slight to moderate degeneration in Langerhans islet cells in all OTA-treated groups. Immunohistochemistry of pancreatic tissue revealed decreased insulin and increased glucagon expression. This study demonstrated that OTA may cause pancreatic damage in the Langerhans islet and predispose rats to DM. View Full-Text
Keywords: Ochratoxin A; insulin; glucagon; glucose; rat plasma; pathology; immunohistochemistry Ochratoxin A; insulin; glucagon; glucose; rat plasma; pathology; immunohistochemistry
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Mor, F.; Sengul, O.; Topsakal, S.; Kilic, M.A.; Ozmen, O. Diabetogenic Effects of Ochratoxin A in Female Rats. Toxins 2017, 9, 144.

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