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Toxins 2018, 10(1), 27; https://doi.org/10.3390/toxins10010027

Correction of Malocclusion by Botulinum Neurotoxin Injection into Masticatory Muscles

1
Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju 28644, Korea
2
Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Korea
*
Author to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 29 December 2017 / Accepted: 31 December 2017 / Published: 2 January 2018
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Abstract

Botulinum toxin (BTX) is a neurotoxin, and its injection in masticatory muscles induces muscle weakness and paralysis. This paralytic effect of BTX induces growth retardation of the maxillofacial bones, changes in dental eruption and occlusion state, and facial asymmetry. Using masticatory muscle paralysis and its effect via BTX, BTX can be used for the correction of malocclusion after orthognathic surgery and mandible fracture. The paralysis of specific masticatory muscles by BTX injection reduces the tensional force to the mandible and prevents relapse and changes in dental occlusion. BTX injection in the anterior belly of digastric and mylohyoid muscle prevents the open-bite and deep bite of dental occlusion and contributes to mandible stability after orthognathic surgery. The effect of BTX injection in masticatory muscles for maxillofacial bone growth and dental occlusion is reviewed in this article. The clinical application of BTX is also discussed for the correction of dental malocclusion and suppression of post-operative relapse after mandibular surgery. View Full-Text
Keywords: botulinum neurotoxin; masticatory system; maxillofacial bone; dental occlusion; orthognathic surgery botulinum neurotoxin; masticatory system; maxillofacial bone; dental occlusion; orthognathic surgery
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Seok, H.; Kim, S.-G. Correction of Malocclusion by Botulinum Neurotoxin Injection into Masticatory Muscles. Toxins 2018, 10, 27.

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