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Toxins 2017, 9(12), 384; https://doi.org/10.3390/toxins9120384

Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A

1
Pathology Department, County Hospital Timisoara, Timisoara 300736, Romania
2
Centre for Environmental Policy, Imperial College London, London SW7 2AZ, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Richard A. Manderville and Annie Pfohl-Leszkowicz
Received: 31 October 2017 / Revised: 21 November 2017 / Accepted: 24 November 2017 / Published: 28 November 2017
(This article belongs to the Collection Ochratoxins-Collection)
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Abstract

Experimental renal cancer caused by ochratoxin A (OTA) in rats was first defined in the US National Toxicology Program (1989) and raised questions about any aetiological role in human urinary tract tumours. A review of histopathology in several rat kidney tumours from dietary OTA in recently described London studies, augmented by clinical immunohistochemistry for the first time for this mycotoxin, establishes their renal tubular cell origin. It had been assumed that the toxin might cause the human urothelial tumours associated with Balkan endemic nephropathy, but the present study could not support this. Comparison with a similar review of a metastasising renal tumour from a female rat of the NTP study consistently shows the kidney as the primary carcinogenic site for OTA. Morphological heterogeneity of these kidney tumours as epithelioid and/or sarcomatoid is revealed. Leiomyosarcoma was also diagnosed, and rhabdomyosarcoma differentiation was observed in the exceptionally aggressive NTP female tumour. The present pilot study involving immunohistochemistry indicates need for wider review of archived tumours for experimental evidence before formulating any epidemiological basis from a rat model for OTA’s relevance to idiopathic human renal cell carcinoma. Although the NTP study concluded that females are less sensitive to OTA than males, some female tumours still had heterogeneous morphology. View Full-Text
Keywords: renal cell carcinoma; ochratoxin A; immunohistochemistry; urothelial cancer; leiomyosarcoma; rhabdomyosarcoma; Balkan endemic nephropathy renal cell carcinoma; ochratoxin A; immunohistochemistry; urothelial cancer; leiomyosarcoma; rhabdomyosarcoma; Balkan endemic nephropathy
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Herman, D.; Mantle, P. Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A. Toxins 2017, 9, 384.

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