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Toxins 2016, 8(5), 153;

The Regulatory Networks That Control Clostridium difficile Toxin Synthesis

Laboratoire Pathogenèse des Bactéries Anaérobes, Department of Microbiology, Institut Pasteur, 25 rue du Dr Roux Paris, Paris 75015, France
UFR Sciences du vivant, University Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, Paris 75015, France
Author to whom correspondence should be addressed.
Academic Editor: Harald Genth
Received: 2 April 2016 / Revised: 3 May 2016 / Accepted: 5 May 2016 / Published: 14 May 2016
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The pathogenic clostridia cause many human and animal diseases, which typically arise as a consequence of the production of potent exotoxins. Among the enterotoxic clostridia, Clostridium difficile is the main causative agent of nosocomial intestinal infections in adults with a compromised gut microbiota caused by antibiotic treatment. The symptoms of C. difficile infection are essentially caused by the production of two exotoxins: TcdA and TcdB. Moreover, for severe forms of disease, the spectrum of diseases caused by C. difficile has also been correlated to the levels of toxins that are produced during host infection. This observation strengthened the idea that the regulation of toxin synthesis is an important part of C. difficile pathogenesis. This review summarizes our current knowledge about the regulators and sigma factors that have been reported to control toxin gene expression in response to several environmental signals and stresses, including the availability of certain carbon sources and amino acids, or to signaling molecules, such as the autoinducing peptides of quorum sensing systems. The overlapping regulation of key metabolic pathways and toxin synthesis strongly suggests that toxin production is a complex response that is triggered by bacteria in response to particular states of nutrient availability during infection. View Full-Text
Keywords: C. difficile; PaLoc; toxin regulation; stress signals; carbon catabolite repression system; growth phase; sporulation; c-di-GMP; quorum sensing C. difficile; PaLoc; toxin regulation; stress signals; carbon catabolite repression system; growth phase; sporulation; c-di-GMP; quorum sensing

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Martin-Verstraete, I.; Peltier, J.; Dupuy, B. The Regulatory Networks That Control Clostridium difficile Toxin Synthesis. Toxins 2016, 8, 153.

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