Combined Effects of Bee Venom Acupuncture and Morphine on Oxaliplatin-Induced Neuropathic Pain in Mice
Abstract
:1. Introduction
2. Results
2.1. Induction of Cold and Mechanical Allodynia by a Single Intraperitoneal Administration of Oxaliplatin in Mice
2.2. Time Course of Dose-Dependent Effects of BVA or Morphine on Oxaliplatin-Induced Cold and Mechanical Allodynia in Mice
2.3. Time Course of Combined Effects of BVA and Morphine on Oxaliplatin-Induced Cold and Mechanical Allodynia in Mice
2.4. Involvement of Spinal Opioidergic and 5-HT3 Receptors but not of α2-Adrenergic Receptors in the Combination Effect of BVA and Morphine on Oxaliplatin-Induced Allodynia in Mice
3. Discussion
4. Experimental Section
4.1. Animals
4.2. Oxaliplatin Administration
4.3. Behavioral Test
4.4. BVA and Morphine Treatment
4.5. Antagonist Treatment
4.6. Statistical Analysis
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Kim, W.; Kim, M.J.; Go, D.; Min, B.-I.; Na, H.S.; Kim, S.K. Combined Effects of Bee Venom Acupuncture and Morphine on Oxaliplatin-Induced Neuropathic Pain in Mice. Toxins 2016, 8, 33. https://doi.org/10.3390/toxins8020033
Kim W, Kim MJ, Go D, Min B-I, Na HS, Kim SK. Combined Effects of Bee Venom Acupuncture and Morphine on Oxaliplatin-Induced Neuropathic Pain in Mice. Toxins. 2016; 8(2):33. https://doi.org/10.3390/toxins8020033
Chicago/Turabian StyleKim, Woojin, Min Joon Kim, Donghyun Go, Byung-Il Min, Heung Sik Na, and Sun Kwang Kim. 2016. "Combined Effects of Bee Venom Acupuncture and Morphine on Oxaliplatin-Induced Neuropathic Pain in Mice" Toxins 8, no. 2: 33. https://doi.org/10.3390/toxins8020033