Next Article in Journal
Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera
Next Article in Special Issue
The Effect of Co-Administration of Death Camas (Zigadenus spp.) and Low Larkspur (Delphinium spp.) in Cattle
Previous Article in Journal
Determination of Gonyautoxin-4 in Echinoderms and Gastropod Matrices by Conversion to Neosaxitoxin Using 2-Mercaptoethanol and Post-Column Oxidation Liquid Chromatography with Fluorescence Detection
Previous Article in Special Issue
Toxicosis by Plant Alkaloids in Humans and Animals in Colombia
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Toxins 2016, 8(1), 12;

Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5

College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China
Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Kevin Welch
Received: 7 December 2015 / Revised: 20 December 2015 / Accepted: 22 December 2015 / Published: 30 December 2015
(This article belongs to the Collection Toxicity of Natural Alkaloids)
Full-Text   |   PDF [2446 KB, uploaded 30 December 2015]   |  


Several species of the genus Veratrum that produce steroid alkaloids are commonly used to treat pain and hypertension in China and Europe. However, Veratrum alkaloids (VAs) induce serious cardiovascular toxicity. In China, Veratrum treatment often leads to many side effects and even causes the death of patients, but the pathophysiological mechanisms under these adverse effects are not clear. Here, two solanidine-type VAs (isorubijervine and rubijervine) isolated from Veratrum taliense exhibited strong cardiovascular toxicity. A pathophysiological study indicated that these VAs blocked sodium channels NaV1.3–1.5 and exhibited the strongest ability to inhibit NaV1.5, which is specifically expressed in cardiac tissue and plays an essential role in cardiac physiological function. This result reveals that VAs exert their cardiovascular toxicity via the NaV1.5 channel. The effects of VAs on NaV1.3 and NaV1.4 may be related to their analgesic effect and skeletal muscle toxicity, respectively. View Full-Text
Keywords: Veratrum taliense; NaV1.5; cardiovascular toxicity Veratrum taliense; NaV1.5; cardiovascular toxicity

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Wang, G.; Rong, M.-Q.; Li, Q.; Liu, Y.-P.; Long, C.-B.; Meng, P.; Yao, H.-M.; Lai, R.; Luo, X.-D. Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5. Toxins 2016, 8, 12.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top