Next Article in Journal
Repetitive Treatment with Diluted Bee Venom Attenuates the Induction of Below-Level Neuropathic Pain Behaviors in a Rat Spinal Cord Injury Model
Next Article in Special Issue
Cabinet of Curiosities: Venom Systems and Their Ecological Function in Mammals, with a Focus on Primates
Previous Article in Journal
Revealing the Function and the Structural Model of Ts4: Insights into the “Non-Toxic” Toxin from Tityus serrulatus Venom
Previous Article in Special Issue
Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates
Open AccessReview

Facing Hymenoptera Venom Allergy: From Natural to Recombinant Allergens

Laboratório de Biologia Molecular de Artrópodes-LBMA-IB-RC-UNESP (Univ Estadual Paulista), Av. 24-A, n_ 1515, Bela Vista, Rio Claro 13506-900, SP, Brazil
Laboratório de Imunologia e Alergia Experimental-LIAE, Departamento de Clínica Médica, Faculdade de Ciências Médicas, FCM, Universidade Estadual de Campinas-UNICAMP, Rua Tessália Vieira de Camargo n_ 126, Cidade Universitária "Zeferino Vaz", Campinas 13083-887, SP, Brazil
Centro de Estudos de Venenos e Animais Peçonhentos-CEVAP (Univ Estadual Paulista), Rua José Barbosa de Barros, 1780, Fazenda Experimental Lageado, Botucatu 18610-307, SP, Brazil
Author to whom correspondence should be addressed.
Academic Editors: Bryan Grieg Fry and Ronald A. Jenner
Toxins 2015, 7(7), 2551-2570;
Received: 20 April 2015 / Revised: 16 May 2015 / Accepted: 23 June 2015 / Published: 9 July 2015
(This article belongs to the Collection Evolution of Venom Systems)
Along with food and drug allergic reactions, a Hymenoptera insect Sting (Apoidea, Vespidae, Formicidae) is one of the most common causes of anaphylaxis worldwide. Diagnoses of Hymenoptera venom allergy (HVA) and specific immunotherapy (SIT) have been based on the use of crude venom extracts. However, the incidence of cross-reactivity and low levels of sensibility during diagnosis, as well as the occurrence of nonspecific sensitization and undesired side effects during SIT, encourage the search for novel allergenic materials. Recombinant allergens are an interesting approach to improve allergy diagnosis and SIT because they circumvent major problems associated with the use of crude venom. Production of recombinant allergens depends on the profound molecular characterization of the natural counterpart by combining some “omics” approaches with high-throughput screening techniques and the selection of an appropriate system for heterologous expression. To date, several clinically relevant allergens and novel venom toxins have been identified, cloned and characterized, enabling a better understanding of the whole allergenic and envenoming processes. Here, we review recent findings on identification, molecular characterization and recombinant expression of Hymenoptera venom allergens and on the evaluation of these heterologous proteins as valuable tools for tackling remaining pitfalls on HVA diagnosis and immunotherapy. View Full-Text
Keywords: Hymenoptera venom; allergy; recombinant allergens; “omics” approaches; diagnosis; immunotherapy Hymenoptera venom; allergy; recombinant allergens; “omics” approaches; diagnosis; immunotherapy
MDPI and ACS Style

Perez-Riverol, A.; Justo-Jacomini, D.L.; Zollner, R.D.L.; Brochetto-Braga, M.R. Facing Hymenoptera Venom Allergy: From Natural to Recombinant Allergens. Toxins 2015, 7, 2551-2570.

AMA Style

Perez-Riverol A, Justo-Jacomini DL, Zollner RDL, Brochetto-Braga MR. Facing Hymenoptera Venom Allergy: From Natural to Recombinant Allergens. Toxins. 2015; 7(7):2551-2570.

Chicago/Turabian Style

Perez-Riverol, Amilcar; Justo-Jacomini, Débora L.; Zollner, Ricardo D.L.; Brochetto-Braga, Márcia R. 2015. "Facing Hymenoptera Venom Allergy: From Natural to Recombinant Allergens" Toxins 7, no. 7: 2551-2570.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop