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Effectiveness of the High Dose/Refuge Strategy for Managing Pest Resistance to Bacillus thuringiensis (Bt) Plants Expressing One or Two Toxins

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Biological Control and Spatial Ecology Laboratory (LUBIES), CP 160/12, Université Libre de Bruxelles, av. FD Roosevelt 50, B-1050 Brussels, Belgium
2
Research Funding for Industry and Agriculture (FRIA, Fonds pour la Formation à la Recherche dans l’Industrie et l’Agriculture), 5 rue d’Egmont, B-1000 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Toxins 2012, 4(10), 810-835; https://doi.org/10.3390/toxins4100810
Received: 6 June 2012 / Revised: 21 September 2012 / Accepted: 8 October 2012 / Published: 18 October 2012
(This article belongs to the Special Issue Insecticidal Toxins)
To delay resistance development to Bacillus thuringiensis (Bt) plants expressing their own insecticide, the application of the Insect Resistance Management strategy called “High Dose/Refuge Strategy” (HD/R) is recommended by the US Environmental Protection Agency (US EPA). This strategy was developed for Bt plants expressing one toxin. Presently, however, new Bt plants that simultaneously express two toxins are on the market. We used a mathematical model to evaluate the efficiency of the HD/R strategy for both these Bt toxins. As the current two-toxin Bt plants do not express two new Cry toxins but reuse one toxin already in use with a one-toxin plant, we estimated the spread of resistance when the resistance alleles are not rare. This study assesses: (i) whether the two toxins have to be present in high concentration, and (ii) the impact of the relative size of the refuge zone on the evolution of resistance and population density. We concluded that for Bt plants expressing one toxin, a high concentration is an essential condition for resistance management. For the pyramided Bt plants, one toxin could be expressed at a low titer if the two toxins are used for the first time, and a small refuge zone is acceptable. View Full-Text
Keywords: insect resistance management; population dynamics; population genetics; Bacillus thuringiensis; High dose/Refuge strategy; Bt plants; two toxins insect resistance management; population dynamics; population genetics; Bacillus thuringiensis; High dose/Refuge strategy; Bt plants; two toxins
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Gryspeirt, A.; Grégoire, J.-C. Effectiveness of the High Dose/Refuge Strategy for Managing Pest Resistance to Bacillus thuringiensis (Bt) Plants Expressing One or Two Toxins. Toxins 2012, 4, 810-835.

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