Next Article in Journal
Hemodynamic Effects of Anthrax Toxins in the Rabbit Model and the Cardiac Pathology Induced by Lethal Toxin
Next Article in Special Issue
Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components
Previous Article in Journal
Developing Resistance to Aflatoxin in Maize and Cottonseed
Previous Article in Special Issue
Use of Ribosome-Inactivating Proteins from Sambucus for the Construction of Immunotoxins and Conjugates for Cancer Therapy
Article Menu

Export Article

Open AccessReview
Toxins 2011, 3(6), 697-720;

Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy

Department of Experimental Pathology, “Alma Mater Studiorum” University of Bologna, via San Giacomo 14, 40126-Bologna, Italy
Author to whom correspondence should be addressed.
Received: 18 April 2011 / Revised: 27 May 2011 / Accepted: 3 June 2011 / Published: 22 June 2011
(This article belongs to the Special Issue Immunotoxins)
Full-Text   |   PDF [282 KB, uploaded 22 June 2011]


Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active A chain (similar to a type 1 RIP) linked to a B chain with lectin properties. RIP-containing conjugates have been used in many experimental strategies against cancer cells, often showing great efficacy in clinical trials. Saporin-S6, a type 1 RIP extracted from Saponaria officinalis L. seeds, has been extensively utilized to construct anti-cancer conjugates because of its high enzymatic activity, stability and resistance to conjugation procedures, resulting in the efficient killing of target cells. This review summarizes saporin-S6-containing conjugates and their application in cancer therapy, considering in-vitro and in-vivo studies both in animal models and in clinical trials. The review is structured on the basis of the targeting of hematological versus solid tumors and on the antigen recognized on the cell surface. View Full-Text
Keywords: saporin-S6; plant toxins; immunotoxins; immunoconjugates; immunotherapy; anti-cancer therapy saporin-S6; plant toxins; immunotoxins; immunoconjugates; immunotherapy; anti-cancer therapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Polito, L.; Bortolotti, M.; Pedrazzi, M.; Bolognesi, A. Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy. Toxins 2011, 3, 697-720.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top