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Toxins 2010, 2(8), 2098-2105;

Ochratoxin A Contamination of Food from Croatia

Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c. 2, 10000 Zagreb, Croatia
Department of Plant Pathology, Faculty of Agriculture, Svetošimunska 25, 10000 Zagreb, Croatia
Author to whom correspondence should be addressed.
Received: 15 July 2010 / Revised: 3 August 2010 / Accepted: 9 August 2010 / Published: 10 August 2010
(This article belongs to the Special Issue Ochratoxins)
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Ochratoxin A (OTA) is a mycotoxin with nephrotoxic, genotoxic and carcinogenic properties produced by Penicillium and Aspergillus moulds under different climatic conditions. Humans and animals are exposed to this compound mainly via ingestion of contaminated food. In Croatia, research on mycotoxins focused on OTA when the mycotoxin theory of endemic nephropathy (EN) was postulated. Ochratoxin A was more frequent and at higher concentration in foods from EN than those from the control regions. Subsequently, OTA concentrations were determined in some commodities intended for human consumption such as maize, wheat, beans and wine. Samples from all parts of Croatia were analyzed and OTA was found in all types of commodities. It was frequently found together with other mycotoxins (fumonisin B1, fumonisin B2 and zearalenone). In general, OTA concentration in foods from Croatia is low, but the frequency of positive samples shows considerable variations from year to year depending also on sampling location. Although low levels of OTA were found in a large proportion of analyzed food samples, its persistent co-occurrence with other significant mycotoxins should raise serious public health concerns as there interactions may be synergistic or additive in causing toxicity in humans and animals. There is need to establish control measures through which such contaminations in foods can be managed. View Full-Text
Keywords: beans; endemic nephropathy; maize; ochratoxin A; wheat; wine beans; endemic nephropathy; maize; ochratoxin A; wheat; wine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Peraica, M.; Flajs, D.; Domijan, A.-M.; Ivić, D.; Cvjetković, B. Ochratoxin A Contamination of Food from Croatia. Toxins 2010, 2, 2098-2105.

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