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Article

Quantitative Proteomic Analysis of Zearalenone-Induced Intestinal Damage in Weaned Piglets

by
Lulu Ma
1,
Yanping Jiang
2,
Fuguang Lu
3,
Shujing Wang
1,
Mei Liu
1,
Faxiao Liu
1,
Libo Huang
1,
Yang Li
1,
Ning Jiao
1,
Shuzhen Jiang
1,
Xuejun Yuan
4,* and
Weiren Yang
1,*
1
College of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, Tai’an 271018, China
2
Zhongcheng Feed Technology Co., Ltd., Feicheng 271600, China
3
Shandong Yucheng Animal Husbandry Development Center Co., Ltd., Yucheng 251200, China
4
College of Life Sciences, Shandong Agricultural University, Tai’an 271018, China
*
Authors to whom correspondence should be addressed.
Toxins 2022, 14(10), 702; https://doi.org/10.3390/toxins14100702
Submission received: 20 September 2022 / Revised: 9 October 2022 / Accepted: 11 October 2022 / Published: 13 October 2022
(This article belongs to the Special Issue Effects of Mycotoxins on Animals)
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Abstract

Zearalenone (ZEN), also known as the F-2 toxin, is a common contaminant in cereal crops and livestock products. This experiment aimed to reveal the changes in the proteomics of ZEN-induced intestinal damage in weaned piglets by tandem mass spectrometry tags. Sixteen weaned piglets either received a basal diet or a basal diet supplemented with 3.0 mg/kg ZEN in a 32 d study. The results showed that the serum levels of ZEN, α-zearalenol, and β-zearalenol were increased in weaned piglets exposed to ZEN (p < 0.05). Zearalenone exposure reduced apparent nutrient digestibility, increased intestinal permeability, and caused intestinal damage in weaned piglets. Meanwhile, a total of 174 differential proteins (DEPs) were identified between control and ZEN groups, with 60 up-regulated DEPs and 114 down-regulated DEPs (FC > 1.20 or <0.83, p < 0.05). Gene ontology analysis revealed that DEPs were mainly involved in substance transport and metabolism, gene expression, inflammatory, and oxidative stress. The Kyoto Encyclopedia of Genes and Genomes analysis revealed that DEPs were significantly enriched in 25 signaling pathways (p < 0.05), most of which were related to inflammation and amino acid metabolism. Our study provides valuable clues to elucidate the possible mechanism of ZEN-induced intestinal injury.
Keywords: zearalenone; weaned piglets; intestine; histology; intestinal permeability; proteomic zearalenone; weaned piglets; intestine; histology; intestinal permeability; proteomic

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MDPI and ACS Style

Ma, L.; Jiang, Y.; Lu, F.; Wang, S.; Liu, M.; Liu, F.; Huang, L.; Li, Y.; Jiao, N.; Jiang, S.; et al. Quantitative Proteomic Analysis of Zearalenone-Induced Intestinal Damage in Weaned Piglets. Toxins 2022, 14, 702. https://doi.org/10.3390/toxins14100702

AMA Style

Ma L, Jiang Y, Lu F, Wang S, Liu M, Liu F, Huang L, Li Y, Jiao N, Jiang S, et al. Quantitative Proteomic Analysis of Zearalenone-Induced Intestinal Damage in Weaned Piglets. Toxins. 2022; 14(10):702. https://doi.org/10.3390/toxins14100702

Chicago/Turabian Style

Ma, Lulu, Yanping Jiang, Fuguang Lu, Shujing Wang, Mei Liu, Faxiao Liu, Libo Huang, Yang Li, Ning Jiao, Shuzhen Jiang, and et al. 2022. "Quantitative Proteomic Analysis of Zearalenone-Induced Intestinal Damage in Weaned Piglets" Toxins 14, no. 10: 702. https://doi.org/10.3390/toxins14100702

APA Style

Ma, L., Jiang, Y., Lu, F., Wang, S., Liu, M., Liu, F., Huang, L., Li, Y., Jiao, N., Jiang, S., Yuan, X., & Yang, W. (2022). Quantitative Proteomic Analysis of Zearalenone-Induced Intestinal Damage in Weaned Piglets. Toxins, 14(10), 702. https://doi.org/10.3390/toxins14100702

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