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Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study

1
Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy
2
Department of Cardiovascular, Endocrine-Metabolic Diseases and Ageing, Istituto Superiore di Sanità, 00161 Rome, Italy
3
Biodonostia, Gastrointestinal Genetics Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 20014 San Sebastian, Spain
4
Gastroenterology and Digestive Endoscopy IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy
5
Digestive Endoscopy UOC CSC03 of the Department of General Surgery, Surgical Specialities “Paride Stefanini”, Policlinic Umberto I, University of Rome ‘Sapienza’, 00161 Rome, Italy
6
Hepatopancreatobiliary Surgery, IRCCS Regina Elena National Cancer Institute, 00114 Rome, Italy
7
Department of Translational and Precision Medicine, Gastroenterology Unit, Policlinic Umberto I, University of Rome ‘Sapienza’, 00161 Rome, Italy
8
Associazione Ricerca Terapie Oncologiche Integrate, 00165 Rome, Italy
9
Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy
10
Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy
11
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy
12
Gastrointestinal Genetics Lab, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, Spain
13
Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain
*
Author to whom correspondence should be addressed.
These two authors equally contributed to the work as first authors.
These two authors equally contributed to the work as last authors.
Toxins 2021, 13(8), 569; https://doi.org/10.3390/toxins13080569
Received: 21 July 2021 / Revised: 6 August 2021 / Accepted: 11 August 2021 / Published: 16 August 2021
Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor progression. Recent data suggest that certain bacterial toxins implicated in DNA attack or in proliferation, replication, and death can be risk factors for insurgence and progression of CRC. In this study, we recruited more than 300 biopsy specimens from people undergoing colonoscopy, and we analyzed to determine whether a correlation exists between the presence of bacterial genes coding for toxins possibly involved in CRC onset and progression and the different stages of CRC. We also analyzed to determine whether CRC-predisposing genetic factors could contribute to bacterial toxins response. Our results showed that CIF toxin is associated with polyps or adenomas, whereas pks+ seems to be a predisposing factor for CRC. Toxins from Escherichia coli as a whole have a higher incidence rate in adenocarcinoma patients compared to controls, whereas Bacteroides fragilis toxin does not seem to be associated with pre-cancerous nor with cancerous lesions. These results have been obtained irrespectively of the presence of CRC-risk loci. View Full-Text
Keywords: bacterial protein toxins; colorectal cancer; gut microbiota screening; mucosa adherent bacteria; host–pathogens interaction; polygenic risk score bacterial protein toxins; colorectal cancer; gut microbiota screening; mucosa adherent bacteria; host–pathogens interaction; polygenic risk score
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MDPI and ACS Style

Piciocchi, A.; Germinario, E.A.P.; Garcia Etxebarria, K.; Rossi, S.; Sanchez-Mete, L.; Porowska, B.; Stigliano, V.; Trentino, P.; Oddi, A.; Accarpio, F.; Grazi, G.L.; Bruno, G.; Bonucci, M.; Giambenedetti, M.; Spigaglia, P.; Barbanti, F.; Owczarek, S.; Luzzi, I.; Delibato, E.; Maroccia, Z.; Nisticò, L.; Fiorentini, C.; D’Amato, M.; De Angelis, R.; Fabbri, A. Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study. Toxins 2021, 13, 569. https://doi.org/10.3390/toxins13080569

AMA Style

Piciocchi A, Germinario EAP, Garcia Etxebarria K, Rossi S, Sanchez-Mete L, Porowska B, Stigliano V, Trentino P, Oddi A, Accarpio F, Grazi GL, Bruno G, Bonucci M, Giambenedetti M, Spigaglia P, Barbanti F, Owczarek S, Luzzi I, Delibato E, Maroccia Z, Nisticò L, Fiorentini C, D’Amato M, De Angelis R, Fabbri A. Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study. Toxins. 2021; 13(8):569. https://doi.org/10.3390/toxins13080569

Chicago/Turabian Style

Piciocchi, Alfonso, Elena Angela Pia Germinario, Koldo Garcia Etxebarria, Silvia Rossi, Lupe Sanchez-Mete, Barbara Porowska, Vittoria Stigliano, Paolo Trentino, Andrea Oddi, Fabio Accarpio, Gian Luca Grazi, Giovanni Bruno, Massimo Bonucci, Massimo Giambenedetti, Patrizia Spigaglia, Fabrizio Barbanti, Slawomir Owczarek, Ida Luzzi, Elisabetta Delibato, Zaira Maroccia, Lorenza Nisticò, Carla Fiorentini, Mauro D’Amato, Roberta De Angelis, and Alessia Fabbri. 2021. "Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study" Toxins 13, no. 8: 569. https://doi.org/10.3390/toxins13080569

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