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Volume 13
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Article

Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) and β-Zearalenol (β-ZEL)

by
Neda Alvarez-Ortega
1,2,
Karina Caballero-Gallardo
1,2,
María Taboada-Alquerque
1,
Jackeline Franco
3,
Elena E. Stashenko
4,
Cristina Juan
5,
Ana Juan-García
5,* and
Jesus Olivero-Verbel
1,*
1
Environmental and Computational Chemistry Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena 130014, Colombia
2
Functional Toxicology Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena 130014, Colombia
3
Metabolite Profiling Facility, Bindley Bioscience Center, Purdue University, 1203 W State St., West Lafayette, IN 47907, USA
4
Center for Chromatography and Mass Spectrometry CROM-MASS, Research Center for Biomolecules CIBIMOL, School of Chemistry, Universidad Industrial de Santander, Bucaramanga 680006, Colombia
5
Facultat de Farmàcia—Avda, Universitat de València, Vicent Andrés Estellés, s/n, 46100 València, Spain
*
Authors to whom correspondence should be addressed.
Toxins 2021, 13(11), 748; https://doi.org/10.3390/toxins13110748
Submission received: 28 September 2021 / Revised: 11 October 2021 / Accepted: 19 October 2021 / Published: 22 October 2021
(This article belongs to the Special Issue Evaluation of Cytotoxicity and Cytoprotection. Effects of Natural Toxins)
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Abstract

Fridericia chica (Bignoniaceae) is a traditional medicinal plant. The aim of this research was to determine the protective effects of the hydroethanolic extract from the F. chica leaves (HEFc) against the cytotoxicity of zearalenone (α-ZEL) and β-ZEL on SH-SY5Y cells. Free radical scavenging activity of HEFc was evaluated using the DPPH method. The cytotoxicity of both zearalenone metabolites and HEFc was examined using MTT test, as was the cytoprotective effects of the HEFc on cells treated with these mycotoxins. The chemical composition of HEFc was determined using UPLC-QTOF-MS/MS. HEFc elicited good DPPH radical scavenging activity following a concentration-dependent relationship. Cells exposed to α-ZEL exhibited a viability ˂50% after 48 h of treatment (25 and 50 µM), while those exposed to β-ZEL showed viability ˂50% (100 µM) and ˂25% (25-100 µM) after 24 and 48 h of exposure, respectively. HEFc showed a significant increase in cell viability after exposure to α-ZEL (25 and 50 µM) and β-ZEL (6–100 µM) (p < 0.05). UPLC-QTOF-MS/MS analyses allowed the identification of 10 phytochemical components in the HEFc. In short, the hydroethanolic extract of F. chica grown in Colombian Caribbean can protect against the effects of mycotoxins and it is a valuable source of compounds with antioxidant properties.
Keywords: cytotoxicity; mycotoxins; Fridericia chica; protection; extracts cytotoxicity; mycotoxins; Fridericia chica; protection; extracts

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MDPI and ACS Style

Alvarez-Ortega, N.; Caballero-Gallardo, K.; Taboada-Alquerque, M.; Franco, J.; Stashenko, E.E.; Juan, C.; Juan-García, A.; Olivero-Verbel, J. Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) and β-Zearalenol (β-ZEL). Toxins 2021, 13, 748. https://doi.org/10.3390/toxins13110748

AMA Style

Alvarez-Ortega N, Caballero-Gallardo K, Taboada-Alquerque M, Franco J, Stashenko EE, Juan C, Juan-García A, Olivero-Verbel J. Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) and β-Zearalenol (β-ZEL). Toxins. 2021; 13(11):748. https://doi.org/10.3390/toxins13110748

Chicago/Turabian Style

Alvarez-Ortega, Neda, Karina Caballero-Gallardo, María Taboada-Alquerque, Jackeline Franco, Elena E. Stashenko, Cristina Juan, Ana Juan-García, and Jesus Olivero-Verbel. 2021. "Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) and β-Zearalenol (β-ZEL)" Toxins 13, no. 11: 748. https://doi.org/10.3390/toxins13110748

APA Style

Alvarez-Ortega, N., Caballero-Gallardo, K., Taboada-Alquerque, M., Franco, J., Stashenko, E. E., Juan, C., Juan-García, A., & Olivero-Verbel, J. (2021). Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) and β-Zearalenol (β-ZEL). Toxins, 13(11), 748. https://doi.org/10.3390/toxins13110748

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