Epidemiological and Clinical Evidence for the Role of Toxins in S. aureus Human Disease
1
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
2
Vanderbilt Vaccine Research Program, Nashville, TN 37232, USA
3
Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA
*
Author to whom correspondence should be addressed.
Toxins 2020, 12(6), 408; https://doi.org/10.3390/toxins12060408
Received: 1 June 2020
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Revised: 12 June 2020
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Accepted: 15 June 2020
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Published: 19 June 2020
(This article belongs to the Special Issue Immunotherapies and Vaccines against Diseases Caused by Staphylococcal Toxins)
Staphylococcus aureus asymptomatically colonizes approximately 30–50% of the population and is a leading cause of bacteremia, bone/joint infections, and skin infections in the US. S. aureus has become a major public health threat due to antibiotic resistance and an increasing number of failed vaccine attempts. To develop new anti-staphylococcal preventive therapies, it will take a more thorough understanding of the current role S. aureus virulence factors play in contributing to human disease. This review focuses on the clinical association of individual toxins with S. aureus infection as well as attempted treatment options. Further understanding of these associations will increase understanding of toxins and their importance to S. aureus pathogenesis.
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Keywords:
Staphylococcus aureus; toxins; vaccines; monoclonal antibodies
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MDPI and ACS Style
Bennett, M.R.; Thomsen, I.P. Epidemiological and Clinical Evidence for the Role of Toxins in S. aureus Human Disease. Toxins 2020, 12, 408. https://doi.org/10.3390/toxins12060408
AMA Style
Bennett MR, Thomsen IP. Epidemiological and Clinical Evidence for the Role of Toxins in S. aureus Human Disease. Toxins. 2020; 12(6):408. https://doi.org/10.3390/toxins12060408
Chicago/Turabian StyleBennett, Monique R., and Isaac P. Thomsen. 2020. "Epidemiological and Clinical Evidence for the Role of Toxins in S. aureus Human Disease" Toxins 12, no. 6: 408. https://doi.org/10.3390/toxins12060408
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