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Open AccessArticle

Phytotoxic Metabolites Isolated from Neufusicoccum batangarum, the Causal Agent of the Scabby Canker of Cactus Pear (Opuntia ficus-indica L.)

1
Dipartimento Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy
2
Dipartimento di Scienze Agrarie, Alimentari, Forestali e Ambientali, Università di Palermo, V. le delle Scienze 4, 90128 Palermo, Italy
3
Dipartimento di Agricoltura, Alimentazione e Ambiente, Università di Catania, Via Santa Sofia 100, 95123 Catania, Italy
4
Dipartimento di Scienze e Tecnologie Agrarie, Alimentari, Ambientali e Forestali, Sez. Patologia vegetale ed entomologia, Università di Firenze, Piazzale delle Cascine 28, 50144 Firenze, Italy
*
Authors to whom correspondence should be addressed.
Toxins 2020, 12(2), 126; https://doi.org/10.3390/toxins12020126
Received: 24 January 2020 / Revised: 13 February 2020 / Accepted: 14 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue Microbial and Plant Phytotoxins)
Six phytotoxins were obtained from the culture filtrates of the ascomycete Neofusicoccum batangarum, the causal agent of the scabby canker of cactus pear (Opuntia ficus-indica L.) in minor Sicily islands. The phytotoxins were identified as (−)-(R)-mellein (1); (±)-botryoisocoumarin A (2); (−)-(3R,4R)- and (−)-(3R,4S)-4-hydroxymellein (3 and 4); (−)-terpestacin (5); and (+)-3,4-dihydro-4,5,8-trihydroxy-3-methylisocoumarin, which we named (+)-neoisocoumarin (6). This identification was done by comparing their spectral and optical data with those already reported in literature. The absolute configuration (3R,4S) to (+)-neoisocoumarin (6) was determined using the advanced Mosher method. All six metabolites were shown to have phytotoxicity on the host (cactus pear) and non-host (tomato) plants, and the most active compounds were (±)-botryoisocoumarin A (2), (−)-terpestacin (5), and (+)-neoisocoumarin (6). View Full-Text
Keywords: cactus pear; scabby cankers; Neofusicoccum batangarum; phytotoxins cactus pear; scabby cankers; Neofusicoccum batangarum; phytotoxins
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MDPI and ACS Style

Masi, M.; Aloi, F.; Nocera, P.; Cacciola, S.O.; Surico, G.; Evidente, A. Phytotoxic Metabolites Isolated from Neufusicoccum batangarum, the Causal Agent of the Scabby Canker of Cactus Pear (Opuntia ficus-indica L.). Toxins 2020, 12, 126.

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