Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish
Abstract
:1. Introduction
2. Results
2.1. H&E and Oil Red-O Stain
2.2. Total Cholesterol and Triglyceride Levels in Liver Tissue
2.3. Marker Gene Transcription of ERS-UPR Pathways
2.4. Transcription of Lipid Metabolism-related Genes
3. Discussion
4. Conclusions
5. Materials and Methods
5.1. Reagents
5.2. Adult Fish Maintenance and MC-LR Treatment
5.3. Histological and Histochemical Examination
5.4. Biochemical Indicator Detection
5.5. qPCR Analysis
5.6. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Zhang, D.; Lin, W.; Liu, Y.; Guo, H.; Wang, L.; Yang, L.; Li, L.; Li, D.; Tang, R. Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish. Toxins 2020, 12, 107. https://doi.org/10.3390/toxins12020107
Zhang D, Lin W, Liu Y, Guo H, Wang L, Yang L, Li L, Li D, Tang R. Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish. Toxins. 2020; 12(2):107. https://doi.org/10.3390/toxins12020107
Chicago/Turabian StyleZhang, Dandan, Wang Lin, Yinjie Liu, Honghui Guo, Lingkai Wang, Liping Yang, Li Li, Dapeng Li, and Rong Tang. 2020. "Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish" Toxins 12, no. 2: 107. https://doi.org/10.3390/toxins12020107
APA StyleZhang, D., Lin, W., Liu, Y., Guo, H., Wang, L., Yang, L., Li, L., Li, D., & Tang, R. (2020). Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish. Toxins, 12(2), 107. https://doi.org/10.3390/toxins12020107