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Article

Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by Modulating Action Potential Threshold in A-Fiber Dorsal Root Ganglia Neurons

by 1,2, 3, 4, 1,2,3,* and 4,*
1
Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Korea
2
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea
3
Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea
4
Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02453, Korea
*
Authors to whom correspondence should be addressed.
Toxins 2020, 12(12), 737; https://doi.org/10.3390/toxins12120737
Received: 30 September 2020 / Revised: 17 November 2020 / Accepted: 20 November 2020 / Published: 24 November 2020
Oxaliplatin is a third-generation platinum-based chemotherapeutic drug widely used in colorectal cancer treatment. Although potent against this tumor, it can induce cold and mechanical allodynia even after a single injection. The currently used drugs to attenuate this allodynia can also cause unwanted effects, which limit their use. Bee venom acupuncture (BVA) is widely used in Korean medicine to treat pain. Although the effect of BVA on oxaliplatin-induced neuropathic pain has been addressed in many studies, its action on dorsal root ganglia (DRG) neurons has never been investigated. A single oxaliplatin injection (6 mg/kg, intraperitoneally) induced cold and mechanical allodynia, and BVA (0.1 and 1 mg/kg, subcutaneous, ST36) dose-dependently decreased allodynia in rats. On acutely dissociated lumbar 4–6 DRG neurons, 10 min application of oxaliplatin (100 μM) shifted the voltage-dependence of sodium conductance toward negative membrane potentials in A- but not C-fibers. The resting membrane potential remained unchanged, but the action potential threshold decreased significantly compared to that of the control (p < 0.05). However, 0.1 μg/mL of BVA administration increased the lowered action potential threshold. In conclusion, these results suggest that BVA may attenuate oxaliplatin-induced neuropathic pain by altering the action potential threshold in A-fiber DRG neurons. View Full-Text
Keywords: action potential; allodynia; bee venom acupuncture; oxaliplatin; voltage-gated sodium channel action potential; allodynia; bee venom acupuncture; oxaliplatin; voltage-gated sodium channel
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MDPI and ACS Style

Lee, J.H.; Gang, J.; Yang, E.; Kim, W.; Jin, Y.-H. Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by Modulating Action Potential Threshold in A-Fiber Dorsal Root Ganglia Neurons. Toxins 2020, 12, 737. https://doi.org/10.3390/toxins12120737

AMA Style

Lee JH, Gang J, Yang E, Kim W, Jin Y-H. Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by Modulating Action Potential Threshold in A-Fiber Dorsal Root Ganglia Neurons. Toxins. 2020; 12(12):737. https://doi.org/10.3390/toxins12120737

Chicago/Turabian Style

Lee, Ji Hwan, Juan Gang, Eunhee Yang, Woojin Kim, and Young-Ho Jin. 2020. "Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by Modulating Action Potential Threshold in A-Fiber Dorsal Root Ganglia Neurons" Toxins 12, no. 12: 737. https://doi.org/10.3390/toxins12120737

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