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Open AccessArticle

Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer

1
State Department of Livestock, Ministry of Agriculture, Livestock, Fisheries and Irrigation Kenya P.O Private bag Kangemi, Nairobi 00100, Kenya
2
Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai Midorimachi, Ebetsu 069-8501, Japan
3
Department of Biosciences, International Livestock Research Institute, P.O. Box 30709, Nairobi 00100, Kenya
4
Department of Public Health and Toxicology, University of Nairobi, P.O. Box 29053, Nairobi 00625, Kenya
5
Department of Clinical Sciences, Swedish University of Agricultural Sciences, P.O. Box 7054, SE-750 07 Uppsala, Sweden
6
Department of Medical Biochemistry and Microbiology, Uppsala University, P.O. Box 582, 75123 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(8), 469; https://doi.org/10.3390/toxins11080469
Received: 24 June 2019 / Revised: 13 July 2019 / Accepted: 25 July 2019 / Published: 10 August 2019
(This article belongs to the Special Issue Dietary Mycotoxin Exposure: Emerging Risks to Human Health)
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Abstract

Milk is an important commodity in Kenya; the country has the largest dairy herd and highest per capita milk consumption in East Africa. As such, hazards in milk are of concern. Aflatoxin M1 (AFM1) is a toxic metabolite of aflatoxin B1 (AFB1) excreted in milk by lactating animals after ingesting AFB1-contaminated feeds. This metabolite is injurious to human health, but there is little information on the risk to human health posed by AFM1 in milk in rural Kenya. To fill this gap, a quantitative risk assessment (QRA) applying probabilistic statistical tools to quantify risks was conducted. This assessed the risk of liver cancer posed by AFM1 in milk, assuming 10-fold lower carcinogenicity than AFB1. Data from four agro–ecological zones in Kenya (semi-arid, temperate, sub-humid and humid) were used. We estimated that people were exposed to between 0.3 and 1 ng AFM1 per kg body weight per day through the consumption of milk. The annual incidence rates of cancer attributed to the consumption of AFM1 in milk were 3.5 × 10−3 (95% CI: 3 × 10−3–3.9 × 10−3), 2.9 × 10−3 (95% CI: 2.5 × 10−3–3.3 × 10−3), 1.4 × 10−3 (95% CI: 1.2 × 10−3–1.5 × 10−3) and 2.7 × 10−3 (95% CI: 2.3 × 10−3–3 × 10−3) cancers per 100,000 in adult females, adult males, children 6–18 years old, and in children less than five years old, respectively. Our results show that aflatoxin exposure from milk contributes relatively little to the incidence of liver cancer. Nonetheless, risk managers should take action based on cumulative exposure from all sources of aflatoxins. View Full-Text
Keywords: mycotoxins; risk assessment; food safety standards; hepatocellular carcinoma; East Africa mycotoxins; risk assessment; food safety standards; hepatocellular carcinoma; East Africa
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Sirma, A.J.; Makita, K.; Grace Randolph, D.; Senerwa, D.; Lindahl, J.F. Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer. Toxins 2019, 11, 469.

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