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Association of Pertussis Toxin with Severe Pertussis Disease

Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
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Toxins 2019, 11(7), 373; https://doi.org/10.3390/toxins11070373
Received: 31 May 2019 / Revised: 17 June 2019 / Accepted: 20 June 2019 / Published: 27 June 2019
(This article belongs to the Special Issue Pertussis Toxin)
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PDF [604 KB, uploaded 27 June 2019]
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Abstract

Pertussis, caused by respiratory tract infection with the bacterial pathogen Bordetella pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and multiply extracellularly in the airways and release several toxins, which have a variety of effects on the host, both local and systemic. Predominant among these toxins is pertussis toxin (PT), a multi-subunit protein toxin that inhibits signaling through a subset of G protein-coupled receptors in mammalian cells. PT activity has been linked with severe and lethal pertussis disease in young infants and a detoxified version of PT is a common component of all licensed acellular pertussis vaccines. The role of PT in typical pertussis disease in other individuals is less clear, but significant evidence supporting its contribution to pathogenesis has been accumulated from animal model studies. In this review we discuss the evidence indicating a role for PT in pertussis disease, focusing on its contribution to severe pertussis in infants, modulation of immune and inflammatory responses to infection, and the characteristic paroxysmal cough of pertussis. View Full-Text
Keywords: Pertussis toxin; bacterial infection; respiratory disease; leukocytosis; pulmonary hypertension; immunomodulation; inflammation; cough Pertussis toxin; bacterial infection; respiratory disease; leukocytosis; pulmonary hypertension; immunomodulation; inflammation; cough
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Scanlon, K.; Skerry, C.; Carbonetti, N. Association of Pertussis Toxin with Severe Pertussis Disease. Toxins 2019, 11, 373.

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