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Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers

Reparto di Sicurezza Chimica degli Alimenti – Istituto Superiore di Sanità, 00161 Rome, Italy
Dipartimento di Chimica – Università “Sapienza”, 00185 Rome, Italy
Servizio Prevenzione Sicurezza Ambienti di Lavoro, SPSAL – AUSL, 42122 Reggio Emilia, Italy
Servizio Epidemiologia, AUSL – IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy
Author to whom correspondence should be addressed.
Toxins 2019, 11(6), 351;
Received: 9 April 2019 / Revised: 22 May 2019 / Accepted: 14 June 2019 / Published: 18 June 2019
(This article belongs to the Special Issue Advanced Methods for Mycotoxins Detection)
PDF [689 KB, uploaded 18 June 2019]


Mycotoxins exposure by inhalation and/or dermal contact is possible in different branches of industry especially where heavily dusty settings are present and the handling of dusty commodities is performed. This study aims to explore the validity of the biomonitoring as a tool to investigate the intake of mycotoxins in a population of workers operating in an Italian feed plant. Serum samples were collected for the determination of aflatoxins B1 (AFB1), AFB1-Lysine adduct and ochratoxin A (OTA). A method based on liquid–liquid extraction coupled with high resolution mass spectrometry determination was developed and fully validated. For AFB1, a high number of non-detected samples (90%) was found and no statistical difference was observed comparing workers and control group. None of the analyzed samples showed the presence of AFB1-Lysine adduct. For OTA, the 100% of the analyzed samples was positive with a 33% of the samples showing a concentration higher than the limit of quantification (LOQ), but no statistical difference was highlighted between the average levels of exposed and control groups. In conclusion, the presence of AFB1 and OTA in serum cannot be attributable to occupational exposure. View Full-Text
Keywords: mycotoxins; biomonitoring; aflatoxin B1; ochratoxin A; occupational exposure mycotoxins; biomonitoring; aflatoxin B1; ochratoxin A; occupational exposure

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De Santis, B.; Debegnach, F.; Sonego, E.; Mazzilli, G.; Buiarelli, F.; Ferri, F.; Giorgi Rossi, P.; Collini, G.; Brera, C. Biomonitoring Data for Assessing Aflatoxins and Ochratoxin A Exposure by Italian Feedstuffs Workers. Toxins 2019, 11, 351.

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