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Characterization of MicroRNA and Gene Expression Profiles Following Ricin Intoxication

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
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Toxins 2019, 11(5), 250; https://doi.org/10.3390/toxins11050250
Received: 25 March 2019 / Revised: 23 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Ricin Toxins)
Ricin, derived from the castor bean plant, is a highly potent toxin, classified as a potential bioterror agent. Current methods for early detection of ricin poisoning are limited in selectivity. MicroRNAs (miRNAs), which are naturally occurring, negative gene expression regulators, are known for their tissue specific pattern of expression and their stability in tissues and blood. While various approaches for ricin detection have been investigated, miRNAs remain underexplored. We evaluated the effect of pulmonary exposure to ricin on miRNA expression profiles in mouse lungs and peripheral blood mononuclear cells (PBMCs). Significant changes in lung tissue miRNA expression levels were detected following ricin intoxication, specifically regarding miRNAs known to be involved in innate immunity pathways. Transcriptome analysis of the same lung tissues revealed activation of several immune regulation pathways and immune cell recruitment. Our work contributes to the understanding of the role of miRNAs and gene expression in ricin intoxication. View Full-Text
Keywords: ricin; microRNA; lung intoxication ricin; microRNA; lung intoxication
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Pillar, N.; Haguel, D.; Grad, M.; Shapira, G.; Yoffe, L.; Shomron, N. Characterization of MicroRNA and Gene Expression Profiles Following Ricin Intoxication. Toxins 2019, 11, 250.

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