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Toxins 2019, 11(3), 154;

Quercetin Inhibits the Proliferation and Aflatoxins Biosynthesis of Aspergillus flavus

Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
National Engineering Research Center of Biological Feed, Beijing 100081, China
State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education & Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 13 February 2019 / Revised: 3 March 2019 / Accepted: 5 March 2019 / Published: 9 March 2019
(This article belongs to the Section Mycotoxins)
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In this work of quercetin’s anti-proliferation action on A. flavus, we revealed that quercetin can effectively hamper the proliferation of A. flavus in dose-effect and time-effect relationships. We tested whether quercetin induced apoptosis in A. flavus via various detection methods, such as phosphatidylserine externalization and Hoechst 33342 staining. The results showed that quercetin had no effect on phosphatidylserine externalization and cell nucleus in A. flavus. Simultaneously, quercetin reduced the levels of reactive oxygen species (ROS). For a better understanding of the molecular mechanism of the A. flavus response to quercetin, the RNA-Seq was used to explore the transcriptomic profiles of A. flavus. According to transcriptome sequencing data, quercetin inhibits the proliferation and aflatoxin biosynthesis by regulating the expression of development-related genes and aflatoxin production-related genes. These results will provide some theoretical basis for quercetin as an anti-mildew agent resource. View Full-Text
Keywords: quercetin; Aspergillus flavus; transcriptome; RNA-seq; aflatoxin quercetin; Aspergillus flavus; transcriptome; RNA-seq; aflatoxin

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Li, X.-M.; Li, Z.-Y.; Wang, Y.-D.; Wang, J.-Q.; Yang, P.-L. Quercetin Inhibits the Proliferation and Aflatoxins Biosynthesis of Aspergillus flavus. Toxins 2019, 11, 154.

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