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Open AccessArticle

Biological Stoichiometry Regulates Toxin Production in Microcystis aeruginosa (UTEX 2385)

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Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX 76798, USA
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Department of Biology, Baylor University, Waco, TX 76798, USA
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The Institute for Ecological, Earth, and Environmental Sciences, Baylor University, Waco, TX 76798, USA
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Department of Chemistry and Biochemistry, Baylor University, Waco, TX 76798, USA
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Department of Environmental Science, Baylor University, Waco, TX 76798, USA
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Institute of Biomedical Studies, Baylor University, Waco, TX 76798, USA
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(10), 601; https://doi.org/10.3390/toxins11100601
Received: 19 September 2019 / Revised: 10 October 2019 / Accepted: 12 October 2019 / Published: 16 October 2019
(This article belongs to the Special Issue Environmental Drivers of Algal and Cyanobacterial Toxin Dynamics)
Harmful algal blooms (HABs) are increasing in magnitude, frequency, and duration globally. Even though a limited number of phytoplankton species can be toxic, they are becoming one of the greatest water quality threats to public health and ecosystems due to their intrinsic toxicity to humans and the numerous interacting factors that undermine HAB forecasting. Here, we show that the carbon:nitrogen:phosphorus (C:N:P) stoichiometry of a common toxic phytoplankton species, Microcystis, regulates toxin quotas during blooms through a tradeoff between primary and secondary metabolism. Populations with optimal C:N (< 8) and C:P (< 200) cellular stoichiometry consistently produced more toxins than populations exhibiting stoichiometric plasticity. Phosphorus availability in water exerted a strong control on population biomass and C:P stoichiometry, but N availability exerted a stronger control on toxin quotas by regulating population biomass and C:N:P stoichiometry. Microcystin-LR, like many phytoplankton toxins, is an N-rich secondary metabolite with a C:N stoichiometry that is similar to the optimal growth stoichiometry of Microcystis. Thus, N availability relative to P and light provides a dual regulatory mechanism that controls both biomass production and cellular toxin synthesis. Overall, our results provide a quantitative framework for improving forecasting of toxin production during HABs and compelling support for water quality management that limit both N and P inputs from anthropogenic sources. View Full-Text
Keywords: ecological stoichiometry; nitrogen; phosphorus; HABs; cyanotoxins; microcystin ecological stoichiometry; nitrogen; phosphorus; HABs; cyanotoxins; microcystin
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Wagner, N.D.; Osburn, F.S.; Wang, J.; Taylor, R.B.; Boedecker, A.R.; Chambliss, C.K.; Brooks, B.W.; Scott, J.T. Biological Stoichiometry Regulates Toxin Production in Microcystis aeruginosa (UTEX 2385). Toxins 2019, 11, 601.

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