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Advanced Proteomics as a Powerful Tool for Studying Toxins of Human Bacterial Pathogens

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SQPOV, UMR0408, Avignon Université, INRA, F-84914 Avignon, France
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Laboratoire Innovations technologiques pour la Détection et le Diagnostic (Li2D), Service de Pharmacologie et Immunoanalyse (SPI), CEA, INRA, F-30207 Bagnols sur Cèze, France
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(10), 576; https://doi.org/10.3390/toxins11100576
Received: 10 August 2019 / Revised: 27 September 2019 / Accepted: 30 September 2019 / Published: 4 October 2019
(This article belongs to the Special Issue Omics Techniques for Toxins Research)
Exotoxins contribute to the infectious processes of many bacterial pathogens, mainly by causing host tissue damages. The production of exotoxins varies according to the bacterial species. Recent advances in proteomics revealed that pathogenic bacteria are capable of simultaneously producing more than a dozen exotoxins. Interestingly, these toxins may be subject to post-transcriptional modifications in response to environmental conditions. In this review, we give an outline of different bacterial exotoxins and their mechanism of action. We also report how proteomics contributed to immense progress in the study of toxinogenic potential of pathogenic bacteria over the last two decades. View Full-Text
Keywords: bacterial toxins; proteomics; human pathogens; B. cereus bacterial toxins; proteomics; human pathogens; B. cereus
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Duport, C.; Alpha-Bazin, B.; Armengaud, J. Advanced Proteomics as a Powerful Tool for Studying Toxins of Human Bacterial Pathogens. Toxins 2019, 11, 576.

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