Next Article in Journal
Development of a Magnetic Nanoparticles-Based Screen-Printed Electrodes (MNPs-SPEs) Biosensor for the Quantification of Ochratoxin A in Cereal and Feed Samples
Next Article in Special Issue
Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells
Previous Article in Journal
Variations of Bacterial Community Composition and Functions in an Estuary Reservoir during Spring and Summer Alternation
Previous Article in Special Issue
Toxicity of Ochratoxin to Early Life Stages of Zebrafish (Danio rerio)
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Toxins 2018, 10(8), 316; https://doi.org/10.3390/toxins10080316

Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks

1
Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil
2
Department of Food Science and Technology, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil
3
Department of Zootechny, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil
4
Department of Preventive Veterinary Medicine, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil
Department of Pathobiology, University of Poonch, Rawalakot-Pakistan 75660, Pakistan.
*
Authors to whom correspondence should be addressed.
Received: 4 July 2018 / Revised: 31 July 2018 / Accepted: 1 August 2018 / Published: 6 August 2018
(This article belongs to the Collection Ochratoxins-Collection)
Full-Text   |   PDF [1399 KB, uploaded 6 August 2018]   |  

Abstract

The mycotoxin, ochratoxin-A (OTA), produced by some fungi, and is a natural contaminant of many foods and animal feeds worldwide. Due to its toxic effects, the recommended maximum daily intake of OTA for poultry feeds is 0.1 mg OTA/kg (ECR2006/575/EC); this dose does not induce changes in hepatic/renal parameters, but decreases thymus size and serum globulin concentrations. Accordingly, in this study, we assessed quantitatively the total circulating IgY and IgA serum levels, in chicks consuming a 0.1 mg OTA/kg diet (limit) and higher doses (0.3–1.1 mg OTA/kg diet) for 14 or 21 days. We also evaluated other immunological parameters (thymus, bursa of Fabricius, and spleen weights and leukocyte profiles) at day 21. Decreased IgY serum levels were observed in all OTA-treated groups (p < 0.05). In the low-dose group, IgA levels were decreased on day 21, but not on day 14. The size of the thymus and the bursa of Fabricius was decreased in all OTA-treated groups (p < 0.05), whereas reduced spleen size and altered leukocyte profiles were detected only in the high-dose group (p < 0.05). We concluded that chronic exposure to OTA, even at the recommended highest dose, affected IgY and IgA production in chicks. View Full-Text
Keywords: IgA; IgY; leukocytes; lymphocytes; mycotoxins; toxins IgA; IgY; leukocytes; lymphocytes; mycotoxins; toxins
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Khan, S.A.; Venancio, E.J.; Fernandes, E.V.; Hirooka, E.Y.; Oba, A.; Flaiban, K.K.M.C.; Itano, E.N. Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks. Toxins 2018, 10, 316.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top