Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks
AbstractThe mycotoxin, ochratoxin-A (OTA), produced by some fungi, and is a natural contaminant of many foods and animal feeds worldwide. Due to its toxic effects, the recommended maximum daily intake of OTA for poultry feeds is 0.1 mg OTA/kg (ECR2006/575/EC); this dose does not induce changes in hepatic/renal parameters, but decreases thymus size and serum globulin concentrations. Accordingly, in this study, we assessed quantitatively the total circulating IgY and IgA serum levels, in chicks consuming a 0.1 mg OTA/kg diet (limit) and higher doses (0.3–1.1 mg OTA/kg diet) for 14 or 21 days. We also evaluated other immunological parameters (thymus, bursa of Fabricius, and spleen weights and leukocyte profiles) at day 21. Decreased IgY serum levels were observed in all OTA-treated groups (p < 0.05). In the low-dose group, IgA levels were decreased on day 21, but not on day 14. The size of the thymus and the bursa of Fabricius was decreased in all OTA-treated groups (p < 0.05), whereas reduced spleen size and altered leukocyte profiles were detected only in the high-dose group (p < 0.05). We concluded that chronic exposure to OTA, even at the recommended highest dose, affected IgY and IgA production in chicks. View Full-Text
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Khan, S.A.; Venancio, E.J.; Fernandes, E.V.; Hirooka, E.Y.; Oba, A.; Flaiban, K.K.M.C.; Itano, E.N. Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks. Toxins 2018, 10, 316.
Khan SA, Venancio EJ, Fernandes EV, Hirooka EY, Oba A, Flaiban KKMC, Itano EN. Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks. Toxins. 2018; 10(8):316.Chicago/Turabian Style
Khan, Shahzad A.; Venancio, Emerson J.; Fernandes, Eduardo V.; Hirooka, Elisa Y.; Oba, Alexandre; Flaiban, Karina K.M.C.; Itano, Eiko N. 2018. "Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks." Toxins 10, no. 8: 316.
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