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Toxins 2018, 10(2), 68; https://doi.org/10.3390/toxins10020068

Candidacidal Activity of a Novel Killer Toxin from Wickerhamomyces anomalus against Fluconazole-Susceptible and -Resistant Strains

1
Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy
2
Department of Biosciences, University of Milan, 20133 Milan, Italy
3
Pediatric Clinical Research Center Romeo and Enrica Invernizzi, Ospedale “Luigi Sacco”, 20157 Milan, Italy
4
School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy
*
Author to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 30 January 2018 / Accepted: 1 February 2018 / Published: 3 February 2018
(This article belongs to the Special Issue Yeast Killer Toxins)
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Abstract

The isolation and characterization from the sand fly Phlebotomus perniciosus of a Wickerhamomyces anomalus yeast strain (Wa1F1) displaying the killer phenotype was recently reported. In the present work, the killer toxin (KT) produced by Wa1F1 was purified and characterized, and its antimicrobial activity in vitro was investigated against fluconazole- susceptible and -resistant clinical isolates and laboratory strains of Candida albicans and C. glabrata displaying known mutations. Wa1F1-KT showed a differential killing ability against different mutant strains of the same species. The results may be useful for the design of therapeutic molecules based on Wa1F1-KT and the study of yeast resistance mechanisms. View Full-Text
Keywords: Wickerhamomyces anomalus; yeast killer toxin; Candida albicans; Candida glabrata; antifungal resistance; Key Contribution; A novel killer toxin produced by the recently isolated Wickerhamomyces anomalus strain 1F1 showed a differential killing ability against fluconazole-susceptible and -resistant Candida clinical isolates and laboratory strains displaying known mutations. Wickerhamomyces anomalus; yeast killer toxin; Candida albicans; Candida glabrata; antifungal resistance; Key Contribution; A novel killer toxin produced by the recently isolated Wickerhamomyces anomalus strain 1F1 showed a differential killing ability against fluconazole-susceptible and -resistant Candida clinical isolates and laboratory strains displaying known mutations.
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Giovati, L.; Santinoli, C.; Ferrari, E.; Ciociola, T.; Martin, E.; Bandi, C.; Ricci, I.; Epis, S.; Conti, S. Candidacidal Activity of a Novel Killer Toxin from Wickerhamomyces anomalus against Fluconazole-Susceptible and -Resistant Strains. Toxins 2018, 10, 68.

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