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A Review of Current Methods for Analysis of Mycotoxins in Herbal Medicines

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
National Research Council of Italy, CNR-ISPA, Via G. Amendola, 122/O, I-70126 Bari, Italy
Authors to whom correspondence should be addressed.
Toxins 2018, 10(2), 65;
Received: 13 December 2017 / Revised: 30 January 2018 / Accepted: 30 January 2018 / Published: 2 February 2018
PDF [1810 KB, uploaded 26 February 2018]


The presence of mycotoxins in herbal medicines is an established problem throughout the entire world. The sensitive and accurate analysis of mycotoxin in complicated matrices (e.g., herbs) typically involves challenging sample pretreatment procedures and an efficient detection instrument. However, although numerous reviews have been published regarding the occurrence of mycotoxins in herbal medicines, few of them provided a detailed summary of related analytical methods for mycotoxin determination. This review focuses on analytical techniques including sampling, extraction, cleanup, and detection for mycotoxin determination in herbal medicines established within the past ten years. Dedicated sections of this article address the significant developments in sample preparation, and highlight the importance of this procedure in the analytical technology. This review also summarizes conventional chromatographic techniques for mycotoxin qualification or quantitation, as well as recent studies regarding the development and application of screening assays such as enzyme-linked immunosorbent assays, lateral flow immunoassays, aptamer-based lateral flow assays, and cytometric bead arrays. The present work provides a good insight regarding the advanced research that has been done and closes with an indication of future demand for the emerging technologies. View Full-Text
Keywords: herbal medicines; mycotoxin; sampling; sample pretreatment; chromatographic methods; rapid detection method herbal medicines; mycotoxin; sampling; sample pretreatment; chromatographic methods; rapid detection method

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Zhang, L.; Dou, X.-W.; Zhang, C.; Logrieco, A.F.; Yang, M.-H. A Review of Current Methods for Analysis of Mycotoxins in Herbal Medicines. Toxins 2018, 10, 65.

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