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Toxins 2018, 10(11), 433;

Current Status and Future Opportunities of Omics Tools in Mycotoxin Research

School of Computing, Engineering, & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK
Food Science and Technology Department, Faculty of Agriculture, University of Tripoli, Tripoli 13538, Libya
National Institute of Fundamental Studies, Hantana Road, Kandy 20000, Sri Lanka
Biochemistry Department, Faculty of Science, Girls Section, King Abdulaziz University, Jeddah 21551, Saudi Arabia
Authors to whom correspondence should be addressed.
Received: 30 September 2018 / Revised: 20 October 2018 / Accepted: 24 October 2018 / Published: 26 October 2018
(This article belongs to the Special Issue Metabolomics in Mycotoxin Research)
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Mycotoxins are toxic secondary metabolites of low molecular weight produced by filamentous fungi, such as Aspergillus, Fusarium, and Penicillium spp. Mycotoxins are natural contaminants of agricultural commodities and their prevalence may increase due to global warming. Dangerous mycotoxins cause a variety of health problems not only for humans, but also for animals. For instance, they possess carcinogenic, immunosuppressive, hepatotoxic, nephrotoxic, and neurotoxic effects. Hence, various approaches have been used to assess and control mycotoxin contamination. Significant challenges still exist because of the complex heterogeneous nature of food composition. The potential of combined omics approaches such as metabolomics, genomics, transcriptomics, and proteomics would contribute to our understanding about pathogen fungal crosstalk as well as strengthen our ability to identify, isolate, and characterise mycotoxins pre and post-harvest. Multi-omics approaches along with advanced analytical tools and chemometrics provide a complete annotation of such metabolites produced before/during the contamination of crops. We have assessed the merits of these individual and combined omics approaches and their promising applications to mitigate the issue of mycotoxin contamination. The data included in this review focus on aflatoxin, ochratoxin, and patulin and would be useful as benchmark information for future research. View Full-Text
Keywords: Aflatoxin; genomic; metabolomics; LC-MS/MS; LC-HRMS; ochratoxin; patulin; proteomics; transcriptomics Aflatoxin; genomic; metabolomics; LC-MS/MS; LC-HRMS; ochratoxin; patulin; proteomics; transcriptomics

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Eshelli, M.; Qader, M.M.; Jambi, E.J.; Hursthouse, A.S.; Rateb, M.E. Current Status and Future Opportunities of Omics Tools in Mycotoxin Research. Toxins 2018, 10, 433.

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