Next Article in Journal
Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King Cobra)
Previous Article in Journal
Multi-Occurrence of Twenty Mycotoxinsin Pasta and a Risk Assessment in the Moroccan Population
Previous Article in Special Issue
Transcriptome Analysis of C. elegans Reveals Novel Targets for DON Cytotoxicity
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Toxins 2018, 10(11), 433; https://doi.org/10.3390/toxins10110433

Current Status and Future Opportunities of Omics Tools in Mycotoxin Research

1
School of Computing, Engineering, & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK
2
Food Science and Technology Department, Faculty of Agriculture, University of Tripoli, Tripoli 13538, Libya
3
National Institute of Fundamental Studies, Hantana Road, Kandy 20000, Sri Lanka
4
Biochemistry Department, Faculty of Science, Girls Section, King Abdulaziz University, Jeddah 21551, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Received: 30 September 2018 / Revised: 20 October 2018 / Accepted: 24 October 2018 / Published: 26 October 2018
(This article belongs to the Special Issue Metabolomics in Mycotoxin Research)
Full-Text   |   PDF [1601 KB, uploaded 26 October 2018]   |  

Abstract

Mycotoxins are toxic secondary metabolites of low molecular weight produced by filamentous fungi, such as Aspergillus, Fusarium, and Penicillium spp. Mycotoxins are natural contaminants of agricultural commodities and their prevalence may increase due to global warming. Dangerous mycotoxins cause a variety of health problems not only for humans, but also for animals. For instance, they possess carcinogenic, immunosuppressive, hepatotoxic, nephrotoxic, and neurotoxic effects. Hence, various approaches have been used to assess and control mycotoxin contamination. Significant challenges still exist because of the complex heterogeneous nature of food composition. The potential of combined omics approaches such as metabolomics, genomics, transcriptomics, and proteomics would contribute to our understanding about pathogen fungal crosstalk as well as strengthen our ability to identify, isolate, and characterise mycotoxins pre and post-harvest. Multi-omics approaches along with advanced analytical tools and chemometrics provide a complete annotation of such metabolites produced before/during the contamination of crops. We have assessed the merits of these individual and combined omics approaches and their promising applications to mitigate the issue of mycotoxin contamination. The data included in this review focus on aflatoxin, ochratoxin, and patulin and would be useful as benchmark information for future research. View Full-Text
Keywords: Aflatoxin; genomic; metabolomics; LC-MS/MS; LC-HRMS; ochratoxin; patulin; proteomics; transcriptomics Aflatoxin; genomic; metabolomics; LC-MS/MS; LC-HRMS; ochratoxin; patulin; proteomics; transcriptomics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Eshelli, M.; Qader, M.M.; Jambi, E.J.; Hursthouse, A.S.; Rateb, M.E. Current Status and Future Opportunities of Omics Tools in Mycotoxin Research. Toxins 2018, 10, 433.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top