The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables
Abstract
1. Colorectal Cancer
2. Cruciferous Vegetables
3. Sulforaphane
4. MicroRNAs
4.1. Biogenesis
4.2. Notes on Nomenclature
4.3. Activities
4.4. IsomiRs
5. Linking Sulforaphane, MicroRNAs, and Colorectal Cancer
5.1. Mechanisms of Sulforaphane-Mediated Modulation
5.2. Interaction of MicroRNAs with Pathogenesis
5.2.1. Interaction with Classic Vogelstein-Model Pathogenesis
5.2.2. Alternative Pathogenesis Model Interaction
6. MicroRNA Assay Methods
6.1. Array-Based Methods
6.2. Cloning and Deep Sequencing
6.3. Comparison of Approaches to MicroRNA Profiling
7. Summary
Acknowledgments
Author Contributions
Conflicts of Interest
References
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MicroRNA | Reported Role in Colorectal Cancer | Reported Target Genes |
---|---|---|
let-7a-5p | Tumour Suppressive | NIRF [57] |
miR-34a-5p | E2F3 [58] | |
miR-101-3p | PTGS2 [59] | |
miR-126-3p | PIK3R2 [60] | |
miR-143-5p | DNMT3A [61]; ERK5 [62] | |
miR-195-5p | BCL2 [63] | |
miR-200a-3p | CTNNB1 [64] | |
miR-150-5p | MUC4 [65]; MYB [66] | |
miR-451a | MIF [67] | |
miR-17-5p | Oncogenic | P130 [68] |
miR-92a-3p | BIM [69] | |
miR-23a-3p | MTSS1 [70] | |
miR-27a-3p | ZBTB10 [71] | |
miR-135b-5p | TGFβR2, DAPK1, APC [72] | |
miR-9-5p | Ambiguous | CDH [73]; TM4SF1 [74] |
miR-21-5p | Pdcd4 [75]; CDC25A [76]; TGFβR2 [77] |
Type of Method | Cost | Relative Time Required | MiRNA Detection |
---|---|---|---|
Array | Medium | Low | Limited to miRNAs known at the time of array development. |
Library-Sequencing | High | High | Can identify and assay novel miRNAs, and retain data for re-mapping against updated miRNA databases. |
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Dacosta, C.; Bao, Y. The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables. Nutrients 2017, 9, 902. https://doi.org/10.3390/nu9080902
Dacosta C, Bao Y. The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables. Nutrients. 2017; 9(8):902. https://doi.org/10.3390/nu9080902
Chicago/Turabian StyleDacosta, Christopher, and Yongping Bao. 2017. "The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables" Nutrients 9, no. 8: 902. https://doi.org/10.3390/nu9080902
APA StyleDacosta, C., & Bao, Y. (2017). The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables. Nutrients, 9(8), 902. https://doi.org/10.3390/nu9080902