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The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women

by Yifan Yang 1,2, Yi Shi 2,3,*, Petri Wiklund 2,4,5,6, Xiao Tan 2,4, Na Wu 1,2, Xiaobo Zhang 1,2, Olli Tikkanen 1,2, Chenhong Zhang 7, Eveliina Munukka 8 and Sulin Cheng 1,2,3,4,*
1
School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
2
Exercise, Health and Technology center, Shanghai Jiao Tong University, Shanghai 200240, China
3
Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China
4
Faculty of Sport and Health Sciences, University of Jyvaskyla, 40014 Jyvaskyla, Finland
5
Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
6
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, SW7 2AZ London, UK
7
State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
8
Department of Medical Microbiology and Immunology, University of Turku, 20014 Turku, Finland
*
Authors to whom correspondence should be addressed.
Nutrients 2017, 9(8), 792; https://doi.org/10.3390/nu9080792
Received: 12 May 2017 / Revised: 10 July 2017 / Accepted: 19 July 2017 / Published: 25 July 2017
The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19–49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO2max) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO2max group (p < 0.05 for all). VO2max was inversely associated with EreC (r = −0.309, p = 0.01) but not with other bacteria. VO2max also negatively correlated with fat% (r = −0.755, p < 0.001), triglycerides (r = −0.274, p = 0.021) and leptin (r = −0.574, p < 0.001). By contrast, EreC was positively associated with fat% (r = 0.382, p = 0.002), dietary fat intake (r = 0.258, p = 0.034), triglycerides (r = 0.390, p = 0.002) and leptin (r = 0.424, p = 0.001), but negatively with carbohydrate intake (r = −0.252, p = 0.034) and HDL (r = −0.26, p = 0.028). After adjusting for age and dietary intake, all the significant associations remained. However, after adjusting for fat%, the associations between VO2max and EreC disappeared. Our results suggest that cardiorespiratory fitness is associated with gut microbiota composition, independent of age and carbohydrate or fat intake. The association between VO2max and EreC, however, appears to be mediated by body fatness. View Full-Text
Keywords: exercise; VO2max; gut microbiota; body fatness exercise; VO2max; gut microbiota; body fatness
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Yang, Y.; Shi, Y.; Wiklund, P.; Tan, X.; Wu, N.; Zhang, X.; Tikkanen, O.; Zhang, C.; Munukka, E.; Cheng, S. The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women. Nutrients 2017, 9, 792.

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